OST4 - oligosaccharyltransferase complex subunit 4, non-catalytic Gene

Homo sapiens

Gene ID: 100128731 | Gene type: protein coding

About OST4

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,070,472-27,071,654 (from NCBI)

This gene has 3 transcripts (splice variants) and 145 orthologues. Ubiquitous expression in colon (RPKM 112.3), adrenal (RPKM 106.4) and 25 other tissues.

Summary

Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

OST4 Products(1)

mRNA	Protein	Name
NM_001134693.2	NP_001128165.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	31831667	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	23606741	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	23606741	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OST4 Protein Structure

Ost4

0
37 a.a.

Protein Preferred Names

Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

oligosaccharyltransferase 4 homolog

OST4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OST4	P0C6T2	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever	Hemorrhagic Fever, Bolivian
Bhf - [Bolivian Haemorrhagic Fever]	Machupo Haemorrhagic Fever

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70172	Heparan Sulfate 3-O-Sulfotransferase 4	Modulator	/	Unkown
HY-RS09854	OST4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OST4	MGD	MGI:1914945
Macaca mulatta	OST4	VGNC	VGNC:106191
Rattus norvegicus	OST4	RGD	RGD:2300150

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