CDH6 - cadherin 6 Gene

Homo sapiens

Also known as CAD6; KCAD

Gene ID: 1004 | Gene type: protein coding

About CDH6

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,193,686-31,329,146 (from NCBI)

This gene has 5 transcripts (splice variants), 263 orthologues and 33 paralogues. Broad expression in kidney (RPKM 6.1), gall bladder (RPKM 4.1) and 17 other tissues.

Summary

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

CDH6 Products(2)

mRNA	Protein	Name
NM_001362435.2	NP_001349364.1	cadherin-6 isoform 2 preproprotein
NM_004932.4	NP_004923.1	cadherin-6 isoform 1 preproprotein

CDH6 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

cadherin-6

cadherin 6, type 2, K-cadherin (fetal kidney)

Recombinant CDH6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7702	Cadherin-6/KCAD Protein, Human (HEK293, Fc)	P55285 (T19-A615)	≥95%
HY-P7703	Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His)	P55285 (T22-A615)	≥95%

Related Diseases

Diseases

Alias

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164734	Raludotatug Deruxtecan		/	Unkown
HY-RS02339	CDH6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDH6	VGNC	VGNC:70974
Mus musculus	CDH6	MGD	MGI:107435
Canis familiaris	CDH6	VGNC	VGNC:50872
Bos taurus	CDH6	VGNC	VGNC:27105
Rattus norvegicus	CDH6	RGD	RGD:2322
Felis catus	CDH6	VGNC	VGNC:60685
Macaca fascicularis	CDH6	NCBI
Others	CDH6	NCBI

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