APELA - apelin receptor early endogenous ligand Gene

Homo sapiens

Also known as ELA; tdl; Ende

Gene ID: 100506013 | Gene type: protein coding

About APELA

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:164,877,178-164,899,007 (from NCBI)

This gene has 5 transcripts (splice variants) and 16 orthologues. Biased expression in prostate (RPKM 1.8), kidney (RPKM 0.5) and 2 other tissues.

Summary

This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/Akt pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]

APELA Products(1)

mRNA	Protein	Name
NM_001297550.2	NP_001284479.1	apelin receptor early endogenous ligand precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables apelin receptor binding	IDA IDA: Inferred from direct assay	28137936	GOA
enables hormone activity	IMP IMP: Inferred from mutant phenotype	25639753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apelin receptor signaling pathway	IDA IDA: Inferred from direct assay	25639753	GOA
involved in apelin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28137936	GOA
involved in positive regulation of G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	25639753	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25639753	GOA
involved in positive regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	28663440	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	24316148	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apelin receptor early endogenous ligand

protein Elabela

Related Diseases

Diseases

Alias

Thyroid Cancer, Nonmedullary, 1

Papillary Thyroid Carcinoma	Familial Nonmedullary Thyroid Cancer, Papillary
Nonmedullary Thyroid Carcinoma, Papillary	Papillary Thyroid Cancer
NMTC1	Papillary Carcinoma Of Thyroid
Pact	Thyroid Carcinoma, Papillary
Non-Medullary Thyroid Carcinoma	Thyroid Cancer, Non-Medullary, 1
Familial Non-Medullary Thyroid Cancer	Fnmtc
Nmtc	Nonmedullary Thyroid Carcinoma
Ptc	Tpc
Thyroid Papillary Carcinoma	Cancer, Thyroid, Nonmedullary
Cancer, Thyroid, Nonmedullary, Type 1	Thyroid Carcinoma, Nonmedullary 1
Familial Nonmedullary Thyroid Gland Carcinoma	Papillary Carcinoma, Diffuse Sclerosing, Thyroid Gland

46,Xy Sex Reversal 8

SRXY8	Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase
Tdd	46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency
46xy Sex Reversal 8	46xy Sex Reversal 8, Modifier Of
Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00814	APELA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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