CDH8 - cadherin 8 Gene

Homo sapiens

Also known as Nbla04261

Gene ID: 1006 | Gene type: protein coding

About CDH8

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:61,647,250-62,036,438 (from NCBI)

This gene has 14 transcripts (splice variants), 213 orthologues and 33 paralogues. Biased expression in brain (RPKM 2.8) and ovary (RPKM 0.2).

Summary

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]

CDH8 Products(2)

mRNA	Protein	Name
NM_001410893.1	NP_001397822.1	cadherin-8 isoform 2
NM_001796.5	NP_001787.2	cadherin-8 isoform 1 preproprotein

CDH8 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
799 a.a.

Protein Preferred Names

Protein Names

cadherin-8

cadherin 8, type 2

Recombinant CDH8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7704	Cadherin-8 Protein, Human (HEK293, His)	P55286 (A30-M621)	≥95%

Related Diseases

Diseases

Alias

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome

Eem Syndrome	Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy
EEMS	Ectodermal Dysplasia-Ectrodactyly-Macular Dystrophy Syndrome
Albrectsen-Svendsen Syndrome	Ohdo-Hirayama-Terawaki Syndrome
Dysplasia, Ectodermal, Ectrodactyly, And Macular Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02341	CDH8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDH8	RGD	RGD:69286
Macaca mulatta	CDH8	VGNC	VGNC:70976
Canis familiaris	CDH8	VGNC	VGNC:39035
Mus musculus	CDH8	MGD	MGI:107434
Bos taurus	CDH8	VGNC	VGNC:109398
Others	CDH8	NCBI

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