ARPC5 - actin related protein 2/3 complex subunit 5 Gene

Homo sapiens

Also known as ARC16; p16-Arc; dJ127C7.3

Gene ID: 10092 | Gene type: protein coding

About ARPC5

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,620,846-183,635,783 (from NCBI)

This gene has 5 transcripts (splice variants), 296 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 104.2), appendix (RPKM 91.8) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

ARPC5 Products(2)

mRNA	Protein	Name
NM_001270439.2	NP_001257368.1	actin-related protein 2月3日 complex subunit 5 isoform 2
NM_005717.4	NP_005708.1	actin-related protein 2月3日 complex subunit 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11162547	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	22378351	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	37349293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC5 Protein Structure

P16-Arc

0
100
151 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2/3 complex subunit 5

Arp2/3 protein complex subunit p16

ARPC5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82109	p16 ARC Antibody (YA1854)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Mandibular Cancer

Mandibular Neoplasms	Malignant Neoplasm Of Inferior Maxilla
Malignant Neoplasm Of Lower Jaw Bone	Malignant Neoplasm Of Mandible
Mandible Cancer	Mandibular Neoplasm
Neoplasm Of Mandible

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145269	AL-GDa62	Inhibitor	/	Unkown
HY-RS01022	ARPC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01023	ARPC5L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARPC5	VGNC	VGNC:53328
Mus musculus	ARPC5	MGD	MGI:1915021
Rattus norvegicus	ARPC5	RGD	RGD:1311791
Bos taurus	ARPC5	VGNC	VGNC:26165

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