2. Gene
  3. ACTR1A - actin related protein 1A Gene

ACTR1A - actin related protein 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARP1; Arp1A; CTRN1

Gene ID: 10121 | Gene type: protein coding

About ACTR1A

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,479,229-102,502,712 (from NCBI)

This gene has 7 transcripts (splice variants), 218 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 46.1), heart (RPKM 30.0) and 25 other tissues.

Summary

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

ACTR1A Products(1)

mRNA Protein Name
NM_005736.4 NP_005727.1 alpha-centractin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28394342 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell cortex IDA
IDA: Inferred from direct assay
22327364 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR1A Protein Structure

Actin

Actin: Actin (9 - 376)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

alpha-centractin

ARP1 actin related protein 1 homolog A

Related Diseases

Diseases Alias
Brachydactyly, Type A3

Brachydactyly Type A3

BDA3

Brachydactyly-Clinodactyly

Brachymesophalangy V

Brachymesophalangy 5

Brachydactyly Clinodactyly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00228 ACTR1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACTR1A MGD MGI:1858964
Bos taurus ACTR1A VGNC VGNC:25585
Rattus norvegicus ACTR1A RGD RGD:1307025
Canis familiaris ACTR1A VGNC VGNC:37552
Felis catus ACTR1A VGNC VGNC:59554
Macaca mulatta ACTR1A VGNC VGNC:69433