RASA4 - RAS p21 protein activator 4 Gene

Homo sapiens

Also known as GAPL; CAPRI

Gene ID: 10156 | Gene type: protein coding

About RASA4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,579,646-102,616,758 (from NCBI)

This gene has 16 transcripts (splice variants), 158 orthologues and 10 paralogues. Ubiquitous expression in endometrium (RPKM 14.7), spleen (RPKM 11.8) and 24 other tissues.

Summary

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to CA(2+). Stimuli that increase intracellular CA(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RASA4 Products(2)

mRNA	Protein	Name
NM_001079877.2	NP_001073346.2	ras GTPase-activating protein 4 isoform 2
NM_006989.6	NP_008920.5	ras GTPase-activating protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	11448776	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	16009725	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	12845332	GOA
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	11448776	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16009725	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	16009725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASA4 Protein Structure

RasGAP

BTK

0
200
400
600
803 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating protein 4

Ca2+-promoted Ras inactivator

Related Diseases

Diseases

Alias

Trachea Carcinoma

Pancoast Tumor	Carcinoma Of The Trachea
Pancoast'S Tumor	Malignant Superior Sulcus Tumor
Malignant Superior Sulcus Tumour	Pancoast Tumour
Pancoast'S Syndrome	Pancoast'S Tumour
Pulmonary Sulcus Tumor	Pulmonary Sulcus Tumour
Superior Pulmonary Sulcus Syndrome	Pancoast Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS11681	RASA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RASA4	MGD	MGI:1858600

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