LPCAT3 - lysophosphatidylcholine acyltransferase 3 Gene

Homo sapiens

Also known as C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5; LPLAT12

Gene ID: 10162 | Gene type: protein coding

About LPCAT3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,976,185-7,018,476 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues.

Summary

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

LPCAT3 Products(1)

mRNA	Protein	Name
NM_005768.6	NP_005759.4	lysophospholipid acyltransferase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18195019	GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	22511767	GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18772128	GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18195019	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18195019	GOA
involved in phosphatidylcholine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18782225	GOA
involved in phosphatidylethanolamine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18772128	GOA
involved in phosphatidylethanolamine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18782225	GOA
involved in phosphatidylserine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18195019	GOA
involved in phosphatidylserine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	18782225	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	18195019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT3 Protein Structure

MBOAT

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

lysophospholipid acyltransferase 5

1-acylglycerophosphocholine O-acyltransferase

Related Diseases

Diseases

Alias

Brachydactyly-Syndactyly Syndrome

BDSD	Brachydactyly-Syndactyly-Oligodactyly Syndrome
Brachydactyly-Syndactyly, Zhao Type	BDSDO

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Inhibitor Pre-designed Sets	Purity	Rare Diseases Unkown
HY-158790	(R)-HTS-3	Inhibitor	99.29%	Unkown
HY-RS07766	LPCAT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LPCAT3	VGNC	VGNC:74405
Felis catus	LPCAT3	VGNC	VGNC:63266
Canis familiaris	LPCAT3	VGNC	VGNC:54322
Bos taurus	LPCAT3	VGNC	VGNC:30963
Rattus norvegicus	LPCAT3	RGD	RGD:1310223
Mus musculus	LPCAT3	MGD	MGI:1315211

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