CHST4 - carbohydrate sulfotransferase 4 Gene

Homo sapiens

Also known as GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST

Gene ID: 10164 | Gene type: protein coding

About CHST4

This gene has 3 transcripts (splice variants), 112 orthologues and 6 paralogues. Restricted expression toward gall bladder (RPKM 42.6).

Summary

This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded Enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

CHST4 Products(2)

mRNA	Protein	Name
NM_001166395.2	NP_001159867.1	carbohydrate sulfotransferase 4
NM_005769.2	NP_005760.1	carbohydrate sulfotransferase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acetylglucosamine 6-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	10330415	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acetylglucosamine metabolic process	IDA IDA: Inferred from direct assay	10330415	GOA
involved in sulfur compound metabolic process	IDA IDA: Inferred from direct assay	10330415	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12855678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST4 Protein Structure

Sulfotransfer_1

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

carbohydrate sulfotransferase 4

GST-3

Related Diseases

Diseases

Alias

Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma	Mucin-Secreting Adenocarcinoma
Mucin-Secreting Carcinoma	Mucous Carcinoma
Pseudomyxoma Peritonei With Unknown Primary Site	Adenocarcinoma, Mucinous

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Developmental And Epileptic Encephalopathy 76

DEE76	Epileptic Encephalopathy, Early Infantile, 76
Eiee76	Decam
Developmental And Epileptic Encephalopathy, 76	Developmental Delay, Epileptic Encephalopathy, Cerebral Atrophy, And Abnormal Myelination
Developmental Delay, Epileptic Endephalopathy, Cerebral Atrophy, And Abnormal Myelination	Early Infantile Epileptic Encephalopathy 76

Cholangiolocellular Carcinoma

Ovarian Mucinous Adenocarcinoma

Mucinous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70164	Carbohydrate Sulfotransferase 4		/	Unkown
HY-RS02690	CHST4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHST4	MGD	MGI:1349479
Macaca mulatta	CHST4	VGNC	VGNC:71057
Felis catus	CHST4	VGNC	VGNC:60891
Bos taurus	CHST4	VGNC	VGNC:27346
Rattus norvegicus	CHST4	RGD	RGD:1310798
Canis familiaris	CHST4	VGNC	VGNC:39256

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