RCAN2 - regulator of calcineurin 2 Gene

Homo sapiens

Also known as CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1

Gene ID: 10231 | Gene type: protein coding

About RCAN2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,220,736-46,491,970 (from NCBI)

This gene has 3 transcripts (splice variants), 155 orthologues and 2 paralogues. Broad expression in heart (RPKM 64.4), brain (RPKM 36.0) and 18 other tissues.

Summary

This gene encodes a member of the regulator of Calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of Calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

RCAN2 Products(3)

mRNA	Protein	Name
NM_001251973.2	NP_001238902.1	calcipressin-2 isoform 2
NM_001251974.2	NP_001238903.1	calcipressin-2 isoform 2
NM_005822.4	NP_005813.2	calcipressin-2 isoform 1

RCAN2 Protein Structure

Calcipressin

0
100
197 a.a.

Protein Preferred Names

Protein Names

calcipressin-2

Down syndrome candidate region 1-like 1

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Spastic Paraplegia 6, Autosomal Dominant

SPG6	Fsp3
Hereditary Spastic Paraplegia 6	Autosomal Dominant Spastic Paraplegia Type 6
Spastic Paraplegia 6	Familial Spastic Paraplegia Autosomal Dominant 3
Familial Spastic Paraplegia, Autosomal Dominant, 3	Autosomal Dominant Familial Spastic Paraplegia Type 3
Autosomal Dominant Spastic Paraplegia 6	Spastic Paraplegia-6
Paraplegia, Spastic, Type 6

Somatization Disorder

Somatoform Disorders	Briquet'S Disorder
Polysomatising Disorder	Somatisation Disorder
Somatoform Disorder

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11780	RCAN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RCAN2	MGD	MGI:1858219
Macaca mulatta	RCAN2	VGNC	VGNC:82092
Rattus norvegicus	RCAN2	RGD	RGD:69198
Canis familiaris	RCAN2	VGNC	VGNC:45437
Felis catus	RCAN2	VGNC	VGNC:64542
Bos taurus	RCAN2	VGNC	VGNC:33821

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