1. Gene
  2. RCAN2 - regulator of calcineurin 2 Gene

RCAN2 - regulator of calcineurin 2 Gene

Homo sapiens

Also known as CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1

Gene ID: 10231 | Gene type: protein coding

About RCAN2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,220,736-46,491,970 (from NCBI)

This gene has 3 transcripts (splice variants), 155 orthologues and 2 paralogues. Broad expression in heart (RPKM 64.4), brain (RPKM 36.0) and 18 other tissues.

Summary

This gene encodes a member of the regulator of Calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of Calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

RCAN2 Products(3)

mRNA Protein Name
NM_001251973.2 NP_001238902.1 calcipressin-2 isoform 2
NM_001251974.2 NP_001238903.1 calcipressin-2 isoform 2
NM_005822.4 NP_005813.2 calcipressin-2 isoform 1

RCAN2 Protein Structure

Calcipressin

Calcipressin: Calcipressin (21 - 190)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

calcipressin-2

Down syndrome candidate region 1-like 1

Related Diseases

Diseases Alias
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Spastic Paraplegia 6, Autosomal Dominant

SPG6

Fsp3

Hereditary Spastic Paraplegia 6

Autosomal Dominant Spastic Paraplegia Type 6

Spastic Paraplegia 6

Familial Spastic Paraplegia Autosomal Dominant 3

Familial Spastic Paraplegia, Autosomal Dominant, 3

Autosomal Dominant Familial Spastic Paraplegia Type 3

Autosomal Dominant Spastic Paraplegia 6

Spastic Paraplegia-6

Paraplegia, Spastic, Type 6

Somatization Disorder

Somatoform Disorders

Briquet'S Disorder

Polysomatising Disorder

Somatisation Disorder

Somatoform Disorder

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus RCAN2 MGD MGI:1858219
Macaca mulatta RCAN2 VGNC VGNC:82092
Rattus norvegicus RCAN2 RGD RGD:69198
Canis familiaris RCAN2 VGNC VGNC:45437
Felis catus RCAN2 VGNC VGNC:64542
Bos taurus RCAN2 VGNC VGNC:33821