MSLN - mesothelin Gene

Homo sapiens

Also known as MPF; SMRP

Gene ID: 10232 | Gene type: protein coding

About MSLN

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:760,734-768,865 (from NCBI)

This gene has 8 transcripts (splice variants), 115 orthologues and 3 paralogues. Biased expression in lung (RPKM 16.4), stomach (RPKM 4.7) and 7 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and Mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

MSLN Products(3)

mRNA	Protein	Name
NM_001177355.3	NP_001170826.1	mesothelin isoform 1 preproprotein
NM_005823.6	NP_005814.2	mesothelin isoform 1 preproprotein
NM_013404.4	NP_037536.2	mesothelin isoform 2 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14676194	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSLN Protein Structure

Mesothelin

0
100
200
300
400
500
630 a.a.

Protein Preferred Names

Protein Names

mesothelin

CAK1 antigen

Recombinant MSLN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70148	Mesothelin Protein, Human (303a.a, HEK293, His)	AAH09272.1 (E296-S598)	≥95%
HY-P70413	Mesothelin Protein, Human (250a.a, HEK293, His)	Q13421 (L37-R286)	≥95%
HY-P72398	Mesothelin Protein, Human (Biotinylated, HEK293, His-Avi)	AAH09272.1 (E296-S598)	≥95%
HY-P73818	Mesothelin Protein, Human (286a.a, HEK293, Fc)	Q13421-2 (M1-R286)	≥95%
HY-P73819	Mesothelin Protein, Human (285a.a, HEK293, Fc)	Q13421-2 (E296-G580)	≥95%
HY-P77546	Mesothelin Protein, Human (Biotinylated, HEK293, Fc)	Q13421-2 (E296-G580)	≥95%
HY-P77547	Mesothelin Protein, Human (Biotinylated, 286a.a, HEK293, His)	Q13421-2 (M1-R286)	≥95%
HY-P78176	Mesothelin Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q13421-2 (E296-G580)	≥95%
HY-P78369	FITC-Labeled Mesothelin Protein, Human (HEK293, Fc)	Q13421-2 (E296-G580)	≥95%
HY-P78370	Mesothelin Protein, Human (HEK293, His-Avi)	Q13421-2 (E296-G580)	≥95%
HY-P78371	FITC-Labeled Mesothelin Protein, Human (HEK293, His-Avi)	Q13421-2 (E296-G580)	≥95%
HY-P700794	Mesothelin Protein, Human (411a.a, HEK293, His)	Q13421-2 (E296-R606)	≥95%

Related Diseases

Diseases

Alias

Benign Mesothelioma

Mesothelioma	Benign Tumor Of Mesothelium
Adenomatoid Tumor

Asbestosis

Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

Pulmonary Fibrosis - From Asbestos Exposure

Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Mesothelioma, Malignant

Malignant Mesothelioma	Pleural Mesothelioma
MESOM	Mesothelioma, Somatic
Advanced Malignant Mesothelioma	Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma	Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To	Mesothelioma Diffuse Malignant
Mesothelioma	Malignant Pleural Mesothelioma

Refractory Hairy Cell Leukemia

Refractory Hematologic Cancer

Refractory Hematologic Malignancy

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Peritoneum Cancer

Peritoneal Neoplasm	Cancer Of Peritoneum
Malignant Tumor Of Peritoneum	Peritoneal Neoplasms

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Thymic Carcinoma

Malignant Thymoma

Thymoma, Malignant

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Pleural Cancer

Pleural Neoplasms	Neoplasm Of Pleura
Pleural Tumor	Malignant Tumor Of Pleura
Pleural Cavity Cancer	Primary Malignant Neoplasm Of Parietal Pleura
Primary Malignant Neoplasm Of Pleura	Primary Malignant Neoplasm Of Visceral Pleura

Pleural Disease

Pleural Diseases	Disorder Of Pleura
Non-Neoplastic Pleural Disease	Pleural Disorders
Non-Neoplastic Pleural Disorder

Malignant Biphasic Mesothelioma

Mesothelioma, Biphasic, Malignant

Mixed Mesothelioma

Malignant Epithelial Mesothelioma

Epithelioid Mesothelioma, Malignant

Liver Fibroma

Fibroma Of The Liver

Liver Solitary Fibrous Tumor

Pericardial Mesothelioma

Malignant Mesothelioma Of Pericardium

Malignant Pericardial Mesothelioma

Fallopian Tube Carcinoma

Fallopian Tube Cancer	Cancer Of The Fallopian Tube
Carcinoma Of Fallopian Tube	Neoplasm Of Fallopian Tube
Fallopian Tube Neoplasms	Fallopian Tube Ca
Fallopian Tube Neoplasm	Malignant Neoplasm Of Uterine Tube
Malignant Tumor Of Fallopian Tube	Malignant Tumour Of Fallopian Tube
Tumor Of The Fallopian Tube	Tumor, Fallopian Tube, Malignant
Malignant Tumor Of Fallopian Tubes	Cancer Of Fallopian Tubes
Malignant Tubal Tumor	Tubal Cancer
Malignant Neoplasm Of Fallopian Tube	Primary Malignant Neoplasm Of Fallopian Tube
Cancer Of The Oviduct

Pericardium Cancer

Malignant Neoplasm Of Pericardium	Malignant Tumor Of Pericardium
Pericardial Tumor	Neoplasm Of Pericardium

Epithelioid Sarcoma

Epithelioid Cell Sarcoma	Sarcoma Epithelioid
Sarcoma, Epithelioid

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Benign Peritoneal Mesothelioma

Mesothelioma Of Peritoneum

Benign Neoplasm Of Mesothelial Tissue Of Peritoneum

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Splenic Tuberculosis

Tuberculosis, Splenic

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99006	Amatuximab	Inhibitor	99.90%	Phase 2
HY-P99352	Anetumab	Inhibitor	≥95.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08719	MSLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99663	Inezetamab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MSLN	RGD	RGD:69333
Macaca mulatta	MSLN	VGNC	VGNC:74936
Mus musculus	MSLN	MGD	MGI:1888992
Macaca fascicularis	MSLN	NCBI	NCBI:102130460
Others	MSLN	NCBI