UBE4B - ubiquitination factor E4B Gene

Homo sapiens

Also known as E4; UFD2; HDNB1; UBOX3; UFD2A

Gene ID: 10277 | Gene type: protein coding

About UBE4B

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:10,032,958-10,181,239 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 12.1), skin (RPKM 10.9) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBE4B Products(3)

mRNA	Protein	Name
NM_001105562.3	NP_001099032.1	ubiquitin conjugation factor E4 B isoform 1
NM_001410744.1	NP_001397673.1	ubiquitin conjugation factor E4 B isoform 3
NM_006048.5	NP_006039.2	ubiquitin conjugation factor E4 B isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20696396	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in granzyme-mediated apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11802788	GOA
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23509263	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	11802788	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE4B Protein Structure

Ufd2P_core

U-box

0
200
400
600
800
1000
1200
1302 a.a.

Protein Preferred Names

Protein Names

ubiquitin conjugation factor E4 B

RING-type E3 ubiquitin transferase E4 B

Related Diseases

Diseases

Alias

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Neuroblastoma 1

Neuroblastoma, Susceptibility To, 1	NBLST1
Neuroblastoma, Susceptibility To, Type 1

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Complement Component 7 Deficiency

C7 Deficiency

C7D

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15372	UBE4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UBE4B	VGNC	VGNC:48073
Bos taurus	UBE4B	VGNC	VGNC:36604
Rattus norvegicus	UBE4B	RGD	RGD:1304738
Mus musculus	UBE4B	MGD	MGI:1927086
Felis catus	UBE4B	VGNC	VGNC:66772
Macaca mulatta	UBE4B	VGNC	VGNC:78700

Name
Email *

	Sorry, but the email address you supplied was invalid.