SIRPB1 - signal regulatory protein beta 1 Gene

Homo sapiens

Also known as CD172b; SIRP-BETA-1

Gene ID: 10326 | Gene type: protein coding

About SIRPB1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,561,385-1,620,009 (from NCBI)

This gene has 15 transcripts (splice variants), 289 orthologues and 4 paralogues. Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase Syk. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

SIRPB1 Products(5)

mRNA	Protein	Name
NM_001083910.4	NP_001077379.1	signal-regulatory protein beta-1 isoform 2 precursor
NM_001135844.4	NP_001129316.1	signal-regulatory protein beta-1 isoform 3 precursor
NM_001329157.2	NP_001316086.1	signal-regulatory protein beta-1 isoform 3 precursor
NM_001330639.2	NP_001317568.1	signal-regulatory protein beta-1 isoform 4 precursor
NM_006065.5	NP_006056.2	signal-regulatory protein beta-1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10940905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRPB1 Protein Structure

V-set

C1-set

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

signal-regulatory protein beta-1

CD172 antigen-like family member B

SIRPB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRPB1	O00241	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	10940905

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRPB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70719	SIRP beta 1 Protein, Human (HEK293, His)	O00241 (E30-E362)	≥95%
HY-P77838	SIRP Beta 1 Protein, Human (isoform 3, HEK293, His-Avi)	Q5TFQ8 (E30-L371)	≥95%
HY-P77839	SIRP Beta 1 Protein, Human (Biotinylated, isoform 3, HEK293, His-Avi)	Q5TFQ8 (E30-L371)	≥95%
HY-P78520	SIRP Beta 1 Protein, Human (HEK293, His-Avi)	O00241 (E30-A369)	≥95%
HY-P700645	SIRP beta 1 Protein, Human (HEK293, His-Myc)	O00241 (E30-L371)	≥95%
HY-P700827	SIRP Beta 1 Protein, Human (Biotinylated, HEK293, C-His-Avi)	O00241-1 (E30-A369)	≥95%

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12933	SIRPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIRPB1	NCBI

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