TYROBP - transmembrane immune signaling adaptor TYROBP Gene

Homo sapiens

Also known as DAP12; KARAP; PLOSL; PLOSL1

Gene ID: 7305 | Gene type: protein coding

About TYROBP

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,904,403-35,908,295 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 147.9), spleen (RPKM 124.2) and 20 other tissues.

Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (Syk) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

TYROBP Products(4)

mRNA	Protein	Name
NM_001173514.2	NP_001166985.1	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
NM_001173515.2	NP_001166986.1	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
NM_003332.4	NP_003323.1	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
NM_198125.3	NP_937758.1	TYRO protein tyrosine kinase-binding protein isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20890284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10799849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9655483	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9655483	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	23459077	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11602640	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	23459077	GOA
involved in myeloid leukocyte activation	IDA IDA: Inferred from direct assay	10604985	GOA
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	21727189	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	26358190	GOA
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	GOA
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	18957693	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	23715743	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	25957402	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23715743	GOA
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: Inferred from direct assay	9655483	GOA
involved in stimulatory killer cell immunoglobulin-like receptor signaling pathway	IDA IDA: Inferred from direct assay	9655483	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell surface	IDA IDA: Inferred from direct assay	10799849	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15294961	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	23459077	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9655483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TYRO protein tyrosine kinase-binding protein

DNAX adaptor protein 12

TYROBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TYROBP	O43914	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	TYROBP	O43914	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	TYROBP	O43914	TYROBP	Homo sapiens	O43914	NMR	20890284
Intra	TYROBP	O43914	TYROBP	Homo sapiens	O43914	Comig Non-Denat Gel	20890284
Intra	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Bait CoIP	10940905
Intra	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Tag CoIP	10940905
Intra	TYROBP	O43914	dap12-tm_nkg2c-tm_fusion_protein	Homo sapiens	EBI-16420154	NMR	20890284

Cross: Cross-species interaction Intra: Intraspecies interaction

TYROBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81906	DAP12 Antibody (YA1651)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Solitary Bone Cyst

Unicameral Bone Cyst	Bone Cysts
Cyst Of Bone	Local Cyst Of Bone
Simple Bone Cyst	Solitary Bone Cyst, Unspecified Site
Traumatic Bone Cyst

Amyotrophic Lateral Sclerosis 3

ALS3	Amyotrophic Lateral Sclerosis Type 3

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia
Alsp	Gpsc
Subcortical Gliosis Of Neumann	Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1
Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids	Hdls
HDLS1	Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia
Gliosis, Familial Progressive Subcortical	Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Pold	Pigmentary Orthochromatic Leukodystrophy
Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Familial Progressive Subcortical Gliosis
Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant	Dementia, Familial, Neumann Type
Adult-Onset Leukodystrophy With Neuroaxonal Spheroids	Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
Neuroaxonal Leukodystrophy	Fpsg
Familial Dementia, Neumann Type	Familial Dementia Neumann Type
Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Speech Disorder

Speech Disorders

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15309	TYROBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TYROBP	VGNC	VGNC:48028
Felis catus	TYROBP	VGNC	VGNC:66740
Mus musculus	TYROBP	MGD	MGI:1277211
Rattus norvegicus	TYROBP	RGD	RGD:1303081
Bos taurus	TYROBP	VGNC	VGNC:36552

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