CDO1 - cysteine dioxygenase type 1 Gene

Homo sapiens

Also known as CDO-I

Gene ID: 1036 | Gene type: protein coding

About CDO1

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,804,733-115,816,659 (from NCBI)

This gene has 4 transcripts (splice variants) and 206 orthologues. Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues.

Summary

Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CDO1 Products(4)

mRNA	Protein	Name
NM_001323565.2	NP_001310494.1	cysteine dioxygenase type 1 isoform 1
NM_001323566.2	NP_001310495.1	cysteine dioxygenase type 1 isoform 3
NM_001323567.2	NP_001310496.1	cysteine dioxygenase type 1 isoform 4
NM_001801.3	NP_001792.2	cysteine dioxygenase type 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine dioxygenase activity	IDA IDA: Inferred from direct assay	17135237	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	17135237	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17135237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDO1 Protein Structure

CDO_I

0
100
200 a.a.

Protein Preferred Names

Protein Names

cysteine dioxygenase type 1

cysteine dioxygenase, type I

Recombinant CDO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70066	CDO1/Cysteine dioxygenase type 1 Protein, Human (His)	Q16878 (M1-N200)	≥95%

Related Diseases

Diseases

Alias

Hepatoblastoma

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine

Tinea Unguium

Dermatophytosis Of Nail	Onychomycosis Due To Dermatophyte
Cellulitis And Abscess	Cellulitis And Abscess Of Buttock
Cellulitis And Abscess Of Face	Cellulitis And Abscess Of Finger
Cellulitis And Abscess Of Finger And Toe	Cellulitis And Abscess Of Gluteal Region
Cellulitis And Abscess Of Trunk	Cellulitis And Abscess Of Upper Arm And Forearm
Dermatophytic Onychia	Dermatophytic Onychomycosis
Onychomycosis	Ringworm Of Nails
Tinea Of Nail

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160525	CDO1 degrader-1	Degrader	/	Unkown
HY-RS02421	CDO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDO1	VGNC	VGNC:60715
Macaca mulatta	CDO1	VGNC	VGNC:110475
Canis familiaris	CDO1	VGNC	VGNC:39075
Mus musculus	CDO1	MGD	MGI:105925
Rattus norvegicus	CDO1	RGD	RGD:69262
Bos taurus	CDO1	VGNC	VGNC:27150
Macaca fascicularis	CDO1	NCBI	NCBI:101866783
Others	CDO1	NCBI

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