Gck - glucokinase Gene

Mus musculus

Also known as Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006

Gene ID: 103988 | Gene type: protein coding

About Gck

Chromosome 11: 5,850,820-5,900,081 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 43 phenotypes. Biased expression in liver adult (RPKM 44.2), liver E18 (RPKM 7.5) and 1 other tissue.

Summary

Enables Glucokinase activity. Involved in calcium ion import; cellular glucose homeostasis; and positive regulation of Insulin secretion. Acts upstream of or within several processes, including carbohydrate phosphorylation; glucose homeostasis; and regulation of Insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; reproductive system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products(2)

mRNA	Protein	Name
NM_001287386.1	NP_001274315.1	hexokinase-4 isoform 2
NM_010292.5	NP_034422.2	hexokinase-4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucokinase activity	IDA IDA: Inferred from direct assay	141272	MGI
enables glucokinase activity	IMP IMP: Inferred from mutant phenotype	7510884	MGI
enables hexokinase activity	IDA IDA: Inferred from direct assay	8530440	MGI
enables hexokinase activity	IMP IMP: Inferred from mutant phenotype	23085254	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12931191	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within NADP metabolic process	IMP IMP: Inferred from mutant phenotype	9873043	MGI
involved in calcium ion import	IMP IMP: Inferred from mutant phenotype	18477811	MGI
acts upstream of or within carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	141272	MGI
acts upstream of or within carbohydrate phosphorylation	IMP IMP: Inferred from mutant phenotype	7556622	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	7556622	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18477811	MGI
acts upstream of or within glucose metabolic process	IDA IDA: Inferred from direct assay	141272	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	7556622	MGI
acts upstream of or within intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	7553875	MGI
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	8530440	MGI
acts upstream of or within positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	7556622	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18477811	MGI
acts upstream of or within regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	8530440	MGI
acts upstream of or within regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	9662046	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	24187134	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12931191	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10713097	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gck Protein Structure

COG5026

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

hexokinase-4

HK IV	hexokinase type IV
hexokinase-D

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147141	HS-276	Inhibitor	98.59%	Unkown
HY-15489	Scriptaid		98.59%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-123714	TL4-12		99.82%	Unkown
HY-RS05329	GCK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05330	Gck Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05331	Gck Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gck	NCBI	NCBI:2645

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