2. Gene
  3. ST3GAL6 - ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Gene

ST3GAL6 - ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SIAT10; ST3GALVI

Gene ID: 10402 | Gene type: protein coding

About ST3GAL6

Cytogenetic location: 3q12.1 Genomic coordinates (GRCh38): 3:98,732,262-98,795,852 (from NCBI)

This gene has 27 transcripts (splice variants), 122 orthologues and 14 paralogues. Broad expression in heart (RPKM 8.2), liver (RPKM 7.6) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Sialyltransferase family. Members of this family are Enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of Selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

ST3GAL6 Products(18)

mRNA Protein Name
NM_001271142.2 NP_001258071.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 2
NM_001271145.2 NP_001258074.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 3
NM_001271146.2 NP_001258075.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NM_001271147.2 NP_001258076.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 4
NM_001271148.2 NP_001258077.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 5
NM_001323352.2 NP_001310281.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NM_001323353.2 NP_001310282.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 5
NM_001323358.2 NP_001310287.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 7
NM_001323359.2 NP_001310288.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 7
NM_001323360.2 NP_001310289.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 2
NM_001323362.2 NP_001310291.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 5
NM_001323363.2 NP_001310292.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 5
NM_001323364.2 NP_001310293.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 5
NM_001323365.2 NP_001310294.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NM_001323366.2 NP_001310295.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 2
NM_001323367.4 NP_001310296.2 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NM_001323368.2 NP_001310297.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NM_006100.4 NP_006091.1 type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

ST3GAL6 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (78 - 329)

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  • 331 a.a.
Protein Preferred Names Protein Names

type 2 lactosamine alpha-2,3-sialyltransferase

CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13851 ST3GAL6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ST3GAL6 VGNC VGNC:65724
Bos taurus ST3GAL6 VGNC VGNC:35335
Rattus norvegicus ST3GAL6 RGD RGD:1303279
Macaca mulatta ST3GAL6 VGNC VGNC:77951
Canis familiaris ST3GAL6 VGNC VGNC:46854
Mus musculus ST3GAL6 MGD MGI:1888707