TUBGCP3 - tubulin gamma complex associated protein 3 Gene

Homo sapiens

Also known as 104p; ALP6; GCP3; Spc98; SPBC98; Spc98p; Grip104

Gene ID: 10426 | Gene type: protein coding

About TUBGCP3

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:112,485,011-112,605,630 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 203 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 8.5), ovary (RPKM 6.0) and 25 other tissues.

Summary

Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule Cytoskeleton organization; and mitotic cell cycle. Located in cytoplasm and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

TUBGCP3 Products(4)

mRNA	Protein	Name
NM_001286277.2	NP_001273206.1	gamma-tubulin complex component 3 isoform 2
NM_001286278.2	NP_001273207.1	gamma-tubulin complex component 3 isoform 3
NM_001286279.2	NP_001273208.1	gamma-tubulin complex component 3 isoform 4
NM_006322.6	NP_006313.1	gamma-tubulin complex component 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	9566969	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9566969	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	9566969	GOA
located in centrosome	IDA IDA: Inferred from direct assay	9566969	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9566969	GOA
located in polar microtubule	IDA IDA: Inferred from direct assay	9566969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUBGCP3 Protein Structure

Spc97_Spc98

0
200
400
600
800
907 a.a.

Protein Preferred Names

Protein Names

gamma-tubulin complex component 3

gamma-ring complex protein 104 kDa

Related Diseases

Diseases

Alias

Pituitary Adenoma 3, Multiple Types

PITA3	Pituitary Adenoma 3, Multiple Types, Somatic
Pituitary Adenoma 3

Combined Oxidative Phosphorylation Deficiency 20

COXPD20	Combined Oxidative Phosphorylation Defect Type 20
Oxidative Phosphorylation Deficiency, Combined, Type 20

Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15263	TUBGCP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TUBGCP3	VGNC	VGNC:79153
Mus musculus	TUBGCP3	MGD	MGI:2183752
Canis familiaris	TUBGCP3	VGNC	VGNC:47993
Felis catus	TUBGCP3	VGNC	VGNC:66705
Rattus norvegicus	TUBGCP3	RGD	RGD:1305726
Bos taurus	TUBGCP3	VGNC	VGNC:36513

Name
Email *

	Sorry, but the email address you supplied was invalid.