CD52 - CD52 molecule Gene

Homo sapiens

Also known as HE5; CDW52; EDDM5

Gene ID: 1043 | Gene type: protein coding

About CD52

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,317,958-26,320,523 (from NCBI)

This gene has 3 transcripts (splice variants) and 54 orthologues. Biased expression in lymph node (RPKM 265.0), spleen (RPKM 195.7) and 9 other tissues.

Summary

Involved in positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region and plasma membrane. Predicted to be intrinsic component of plasma membrane. Predicted to be active in sperm midpiece. [provided by Alliance of Genome Resources, Apr 2022]

CD52 Products(1)

mRNA	Protein	Name
NM_001803.3	NP_001794.2	CAMPATH-1 antigen precursor

CD52 Protein Structure

CD52

0
61 a.a.

Protein Preferred Names

Protein Names

CAMPATH-1 antigen

CD52 antigen (CAMPATH-1 antigen)

Recombinant CD52 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72123	CD52 Protein, Human (His)	P31358 (G25-S36)	≥95%
HY-P72360	CD52 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P31358 (G25-S36)	≥95%
HY-P75399	CD52 Protein, Human (HEK293, hFc)	P31358 (G25-S36)	≥95%
HY-P78411	CD52 Protein, Human (HEK293, mFc)	P31358 (G25-S36)	≥95%

Related Diseases

Diseases

Alias

Listeria Meningitis

Meningitis, Listeria

T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, T-Cell Type
T-Pll	T-Cell Chronic Lymphocytic Leukemia
Lymphocytic Leukemia T-Cell Chronic	Doid:0081042
Leukemia, T-Cell, Chronic	Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Hemoglobinuria

Disseminated Eosinophilic Collagen Disease

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Goodpasture Syndrome

Anti-Glomerular Basement Membrane Disease	Anti-Gbm Disease
Pulmonary Renal Syndrome	Anti-Glomerular Basement Membrane Antibody Disease
Glomerulonephritis - Pulmonary Hemorrhage	Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage
Anti-Gbm Syndrome	Goodpasture'S Syndrome
Anti-Basement Membrane Glomerulonephritis

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Acalculous Cholecystitis

Acute Cholecystitis Without Calculus	Acute Acalculous Cholecystitis
Cholecystitis Without Calculus

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Prolymphocytic Leukemia

Pll	Prolymphocytic Leukaemia
Leukemia Prolymphocytic	Leukemia, Prolymphocytic

Primary Thrombocytopenia

Autoimmune Disease Of Urogenital Tract

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Lymphoproliferative Syndrome 1

LPFS1	Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1
Combined Immunodeficiency Due To Itk Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Itk Deficiency
Itk Deficiency

Pure Red-Cell Aplasia

Pure Red Cell Aplasia	Primary Red Cell Aplasia
Red Cell Hypoplasia	Prca
Red-Cell Aplasia Pure	Red-Cell Aplasia, Pure

Autoimmune Disease Of Blood

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Opportunistic Bacterial Infectious Disease

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia	Idiopathic Autoimmune Hemolytic Anemia
Immuno-Hemolytic Anemia	Anemia, Hemolytic, Autoimmune
Autoimmune Haemolytic Anaemia	Autoimmune Hemolytic Anaemia
Acquired Autoimmune Hemolytic Anemia	Anemia Hemolytic Autoimmune
Familial Auto-Immune Hemolytic Anemia	Aha
Aiha

Pneumocystosis

Pneumocystis Jirovecii Pneumonia	Pneumocystis Carinii Pneumonia
Pneumocystis Pneumonia	Pulmonary Pneumocystosis
PCP	Pneumocystosis Pneumonia
Pneumonia Pneumocystis Carinii	Pneumonia, Pneumocystis
Pneumocystis Jiroveci Pneumonia

T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma	Adult Precursor T Lymphoblastic Leukemia
Atll	T-Cell Adult Acute Lymphoblastic Leukemia

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura	Autoimmune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura	Itp
Idiopathic Purpura	AITP
Ideopath Thrombocytopenic Pur	Primary Thrombocytopenic Purpura
Werlhof'S Disease	Thrombocytopenic Purpura Autoimmune
Purpura Thrombocytopenic Idiopathic	Purpura, Thrombocytopenic, Idiopathic
Autoimmune Thrombocytopenia	Thrombocytopenia Due To Platelet Alloimmunization
Idiopathic Thrombocytopenia	Idiopathic Thrombocytopenia Purpura
Frank'S Essential Thrombocytopenia	Itp - [Idiopathic Thrombocytopenia Purpura]
Werlhof Disease	Primary Autoimmune Thrombocytopenic Purpura
Haemorrhagic Purpura	Essential Thrombocytopenia
Purpura Haemorrhagica

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Hemorrhagic Cystitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9948	Alemtuzumab	Inducer	97.15%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02253	CD52 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD52	VGNC	VGNC:27038
Canis familiaris	CD52	VGNC	VGNC:38963
Mus musculus	CD52	MGD	MGI:1346088
Rattus norvegicus	CD52	RGD	RGD:620627
Macaca mulatta	CD52	VGNC	VGNC:70819
Felis catus	CD52	VGNC	VGNC:81194
Macaca fascicularis	CD52	NCBI	NCBI:102144354
Others	CD52	NCBI

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