Pik3r6 - phosphoinositide-3-kinase regulatory subunit 5 Gene

Mus musculus

Also known as p84; p87PIKAP; p84 PIKAP; p87(PIKAP)

Gene ID: 104709 | Gene type: protein coding

About Pik3r6

Summary

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Pik3r6 Products(2)

mRNA	Protein	Name
NM_001004435.3	NP_001004435.1	phosphoinositide 3-kinase regulatory subunit 6 isoform 2
NM_001081566.2	NP_001075035.1	phosphoinositide 3-kinase regulatory subunit 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA IDA: Inferred from direct assay	15797027	MGI
contributes to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	19906996	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15797027	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19906996	MGI
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	19906996	MGI
involved in positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	12707323	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	19906996	MGI
part of phosphatidylinositol 3-kinase complex, class IB	IDA IDA: Inferred from direct assay	15797027	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphoinositide 3-kinase regulatory subunit 6

p84 PI3K adapter protein	p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
phosphoinositide 3-kinase gamma adapter protein of 87 kDa	phosphoinositide-3-kinase, regulatory subunit 6

Pik3r6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pik3r6	Q3U6Q4	Pik3cg	Mus musculus	Q9JHG7	Anti Bait CoIP	15797027
Intra	Pik3r6	Q3U6Q4	Pik3cg	Mus musculus	Q9JHG7	Anti Bait CoIP	23824069

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10541	PIK3R6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3r6	NCBI	NCBI:146850

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