ENOX2 - ecto-NOX disulfide-thiol exchanger 2 Gene

Homo sapiens

Also known as APK1; tNOX; COVA1

Gene ID: 10495 | Gene type: protein coding

About ENOX2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,622,325-130,903,209 (from NCBI)

This gene has 7 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues.

Summary

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ENOX2 Products(10)

mRNA	Protein	Name
NM_001281736.2	NP_001268665.1	ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_001382516.1	NP_001369445.1	ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382517.1	NP_001369446.1	ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382518.1	NP_001369447.1	ecto-NOX disulfide-thiol exchanger 2 isoform c
NM_001382519.1	NP_001369448.1	ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382520.1	NP_001369449.1	ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382521.1	NP_001369450.1	ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_001382522.1	NP_001369451.1	ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_006375.4	NP_006366.2	ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_182314.3	NP_872114.1	ecto-NOX disulfide-thiol exchanger 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in electron transport chain	IDA IDA: Inferred from direct assay	11888291	GOA
involved in ultradian rhythm	IDA IDA: Inferred from direct assay	12356293	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11488599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOX2 Protein Structure

RRM_1

0
100
200
300
400
500
610 a.a.

Protein Preferred Names

Protein Names

ecto-NOX disulfide-thiol exchanger 2

APK1 antigen

Related Diseases

Diseases

Alias

Suppressor Of Tumorigenicity 3

Cervical Carcinoma	ST3
Tumor-Suppressor Gene, Hela Cell Type	Tshl
Cervical Carcinoma, Tumor-Suppressor Gene Involved In	Ccts
Cervix Carcinoma

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04385	ENOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENOX2	VGNC	VGNC:106725
Felis catus	ENOX2	VGNC	VGNC:61870
Rattus norvegicus	ENOX2	RGD	RGD:1563643
Macaca mulatta	ENOX2	VGNC	VGNC:72086
Canis familiaris	ENOX2	VGNC	VGNC:40372
Mus musculus	ENOX2	MGD	MGI:2384799

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