SEMA4F - ssemaphorin 4F Gene

Homo sapiens

Also known as S4F; SEMAM; SEMAW; M-SEMA; PRO2353; m-Sema-M

Gene ID: 10505 | Gene type: protein coding

About SEMA4F

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,654,247-74,709,713 (from NCBI)

This gene has 10 transcripts (splice variants), 182 orthologues and 19 paralogues. Broad expression in brain (RPKM 2.1), testis (RPKM 1.1) and 22 other tissues.

Summary

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate Cancer, the development of neurofibromas, and breast Cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SEMA4F Products(3)

mRNA	Protein	Name
NM_001271661.2	NP_001258590.1	semaphorin-4F isoform 2 precursor
NM_001271662.2	NP_001258591.1	semaphorin-4F isoform 3 precursor
NM_004263.5	NP_004254.2	semaphorin-4F isoform 1 precursor

SEMA4F Protein Structure

Sema

PSI

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

semaphorin-4F

sema domain immunoglobulin domain transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 4F

Related Diseases

Diseases

Alias

Dyslexia

Diffuse Glomerulonephritis

Glomerulonephritis Diffuse

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12661	SEMA4F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEMA4F	VGNC	VGNC:77167
Canis familiaris	SEMA4F	VGNC	VGNC:45997
Bos taurus	SEMA4F	VGNC	VGNC:34437
Mus musculus	SEMA4F	MGD	MGI:1340055
Rattus norvegicus	SEMA4F	RGD	RGD:3658

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