2. Gene
  3. SEMA4D - semaphorin 4D Gene

SEMA4D - semaphorin 4D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

Gene ID: 10507 | Gene type: protein coding

About SEMA4D

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,360,787-89,498,113 (from NCBI)

This gene has 24 transcripts (splice variants), 192 orthologues, 19 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues.

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of neuron projection development; and regulation of phosphate metabolic process. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4D Products(11)

mRNA Protein Name
NM_001142287.2 NP_001135759.1 semaphorin-4D isoform 2 precursor
NM_001371194.2 NP_001358123.1 semaphorin-4D isoform 1 precursor
NM_001371195.1 NP_001358124.1 semaphorin-4D isoform 1 precursor
NM_001371196.1 NP_001358125.1 semaphorin-4D isoform 1 precursor
NM_001371197.1 NP_001358126.1 semaphorin-4D isoform 1 precursor
NM_001371198.1 NP_001358127.1 semaphorin-4D isoform 2 precursor
NM_001371199.1 NP_001358128.1 semaphorin-4D isoform 2 precursor
NM_001371200.1 NP_001358129.1 semaphorin-4D isoform 2 precursor
NM_001371201.1 NP_001358130.1 semaphorin-4D isoform 2 precursor
NM_001371202.1 NP_001358131.1 semaphorin-4D isoform 3 precursor
NM_006378.4 NP_006369.3 semaphorin-4D isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20877282 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20877282 GOA
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
15218527 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
15613544 GOA
enables signaling receptor binding IDA
IDA: Inferred from direct assay
11254688 GOA
enables transmembrane signaling receptor activity IMP
IMP: Inferred from mutant phenotype
20877282 GOA
Biological Process GO Annotation Evidence Reference Source
involved in leukocyte aggregation IMP
IMP: Inferred from mutant phenotype
8876214 GOA
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
15218527 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22019888 GOA
involved in ossification involved in bone maturation IMP
IMP: Inferred from mutant phenotype
22019888 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
19788569 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
16055703 GOA
involved in positive regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
19788569 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16055703 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
16055703 GOA
involved in regulation of cell projection organization IMP
IMP: Inferred from mutant phenotype
20877282 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
20877282 GOA
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
19788569 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
15218527 GOA
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
19788569 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8876214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA4D Protein Structure

Sema

Sema: Sema domain (50 - 481)

PSI

PSI: Plexin repeat (503 - 554)

ig

ig: Immunoglobulin domain (569 - 624)

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  • 862 a.a.
Protein Preferred Names Protein Names

semaphorin-4D

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Recombinant SEMA4D Proteins

Cat. No. Product Name Accession Purity
HY-P7774 Semaphorin-4D/SEMA4D Protein, Human (713a.a, HEK293, His) Q92854-1 (M22-R734) ≥95%
HY-P74565 Semaphorin-4D/SEMA4D Protein, Human (HEK293, hFc) AAH54500.1 (M22-R734) ≥95%
HY-P77194 Semaphorin-4D/SEMA4D Protein, Rhesus Macaque (HEK293, His) EHH24221.1 (M22-R734) ≥95%
HY-P78202 Semaphorin-4D/SEMA4D Protein, Human (Biotinylated, HEK293, His-Avi) Q92854-1 (M22-R734) ≥95%
HY-P78512 Semaphorin-4D/SEMA4D Protein, Human (HEK293, His-Avi) Q92854-1 (M22-R734) ≥95%

Related Diseases

Diseases Alias
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Osteonecrosis Of The Jaw
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12660 SEMA4D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SEMA4D VGNC VGNC:34436
Canis familiaris SEMA4D VGNC VGNC:53974
Mus musculus SEMA4D MGD MGI:109244
Macaca mulatta SEMA4D VGNC VGNC:77166
Felis catus SEMA4D VGNC VGNC:64995
Rattus norvegicus SEMA4D RGD RGD:1310554
Macaca fascicularis SEMA4D NCBI NCBI:102132571
Others SEMA4D NCBI