MYBBP1A - MYB binding protein 1a Gene

Homo sapiens

Also known as P160; PAP2; Pol5

Gene ID: 10514 | Gene type: protein coding

About MYBBP1A

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,538,904-4,555,384 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MYBBP1A Products(2)

mRNA	Protein	Name
NM_001105538.2	NP_001099008.1	myb-binding protein 1A isoform 1
NM_014520.4	NP_055335.2	myb-binding protein 1A isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21471221	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	21471221	GOA
involved in positive regulation of anoikis	IMP IMP: Inferred from mutant phenotype	23388179	GOA
involved in positive regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	16603771	GOA
acts upstream of negative effect regulation of G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	21471221	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of B-WICH complex	IDA IDA: Inferred from direct assay	16603771	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	21471221	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21471221	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYBBP1A Protein Structure

DNA_pol_phi

0
300
600
900
1200
1328 a.a.

Protein Preferred Names

Protein Names

myb-binding protein 1A

MYB binding protein (P160) 1a

MYBBP1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81642	MYBBP1A Antibody (YA1387)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

CMTX3	Charcot-Marie-Tooth Disease X-Linked Recessive 3
Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3	Cmt3x
X-Linked Charcot-Marie-Tooth Disease Type 3	Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3
Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08870	MYBBP1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYBBP1A	VGNC	VGNC:43519
Macaca mulatta	MYBBP1A	VGNC	VGNC:75090
Felis catus	MYBBP1A	VGNC	VGNC:68370
Rattus norvegicus	MYBBP1A	RGD	RGD:62062
Bos taurus	MYBBP1A	VGNC	VGNC:31777
Mus musculus	MYBBP1A	MGD	MGI:106181

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