2. Gene
  3. IPO7 - importin 7 Gene

IPO7 - importin 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Imp7; RANBP7

Gene ID: 10527 | Gene type: protein coding

About IPO7

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,384,652-9,448,127 (from NCBI)

This gene has 8 transcripts (splice variants), 219 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 38.5), urinary bladder (RPKM 24.9) and 25 other tissues.

Summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

IPO7 Products(1)

mRNA Protein Name
NM_006391.3 NP_006382.1 importin-7
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables SMAD binding IPI
IPI: Inferred from physical interaction
26878725 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15282309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPO7 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (22 - 100)

Cse1

Cse1: Cse1 (198 - 440)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1038 a.a.
Protein Preferred Names Protein Names

importin-7

RAN-binding protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06870 IPO7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IPO7 RGD RGD:1310849
Felis catus IPO7 VGNC VGNC:69233
Mus musculus IPO7 MGD MGI:2152414
Bos taurus IPO7 VGNC VGNC:30244
Macaca mulatta IPO7 VGNC VGNC:97778
Canis familiaris IPO7 VGNC VGNC:42067