UPK3B - uroplakin 3B Gene

Homo sapiens

Also known as P35; UP3B; UPIIIB

Gene ID: 105375355 | Gene type: protein coding

About UPK3B

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,510,552-76,516,522 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 141 orthologues and 3 paralogues. Biased expression in lung (RPKM 16.8), urinary bladder (RPKM 3.5) and 2 other tissues.

Summary

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

UPK3B Products(4)

mRNA	Protein	Name
NM_001347684.2	NP_001334613.1	uroplakin-3b isoform d precursor
NM_030570.3	NP_085047.1	uroplakin-3b isoform a precursor
NM_182683.2	NP_872624.1	uroplakin-3b isoform c precursor
NM_182684.2	NP_872625.1	uroplakin-3b isoform b precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18776082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

uroplakin-3b

uroplakin IIIb

Related Diseases

Diseases

Alias

Holocarboxylase Synthetase Deficiency

HLCS DEFICIENCY	Early-Onset Multiple Carboxylase Deficiency
Biotin- Ligase Deficiency	Neonatal Multiple Carboxylase Deficiency
Multiple Carboxylase Deficiency, Neonatal Form	Multiple Carboxylase Deficiency, Early Onset
Multiple Carboxylase Deficiency - Neonatal Onset	Early-Onset Biotin-Responsive Multiple Carboxylase Deficiency
Early-Onset Combined Carboxylase Deficiency	Infantile Multiple Carboxylase Deficiency
Biotin-Responsive Mcd	Biotin-Responsive Multiple Carboxylase Deficiency
Early-Onset Mcd	Mcd Neonatal Form

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15489	UPK3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UPK3B	MGD	MGI:2140882
Canis familiaris	UPK3B	VGNC	VGNC:106616
Rattus norvegicus	UPK3B	RGD	RGD:1309615
Felis catus	UPK3B	VGNC	VGNC:107075
Bos taurus	UPK3B	VGNC	VGNC:107016

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