2. Gene
  3. ARPC1A - actin related protein 2/3 complex subunit 1A Gene

ARPC1A - actin related protein 2/3 complex subunit 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307

Gene ID: 10552 | Gene type: protein coding

About ARPC1A

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,325,898-99,366,262 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

ARPC1A Products(2)

mRNA Protein Name
NM_001190996.2 NP_001177925.1 actin-related protein 2月3日 complex subunit 1A isoform 2
NM_006409.4 NP_006400.2 actin-related protein 2月3日 complex subunit 1A isoform 1

ARPC1A Protein Structure

WD40

WD40: WD domain, G-beta repeat (45 - 80)

WD40

WD40: WD domain, G-beta repeat (135 - 170)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 1A

SOP2-like protein

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group G

Fanconi Anemia Complementation Group G

FANCG
Scapuloperoneal Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01013 ARPC1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARPC1A VGNC VGNC:50215
Mus musculus ARPC1A MGD MGI:1928896
Canis familiaris ARPC1A VGNC VGNC:49924
Rattus norvegicus ARPC1A RGD RGD:620834
Felis catus ARPC1A VGNC VGNC:80551