HTATIP2 - HIV-1 Tat interactive protein 2 Gene

Homo sapiens

Also known as CC3; TIP30; SDR44U1

Gene ID: 10553 | Gene type: protein coding

About HTATIP2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,363,714-20,383,782 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in duodenum (RPKM 33.4), small intestine (RPKM 30.9) and 24 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

HTATIP2 Products(5)

mRNA	Protein	Name
NM_001098520.2	NP_001091990.1	oxidoreductase HTATIP2 isoform a precursor
NM_001098521.2	NP_001091991.1	oxidoreductase HTATIP2 isoform b
NM_001098522.2	NP_001091992.1	oxidoreductase HTATIP2 isoform b
NM_001098523.2	NP_001091993.1	oxidoreductase HTATIP2 isoform c
NM_006410.5	NP_006401.3	oxidoreductase HTATIP2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15282309	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10698937	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in import into nucleus	IDA IDA: Inferred from direct assay	15282309	GOA
acts upstream of or within positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	10698937	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10698937	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	10698937	GOA
involved in regulation of angiogenesis	IDA IDA: Inferred from direct assay	11313954	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15282309	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	15282309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTATIP2 Protein Structure

NAD_binding_10

0
100
200
242 a.a.

Protein Preferred Names

Protein Names

oxidoreductase HTATIP2

30 kDa HIV-1 TAT-interacting protein

Related Diseases

Diseases

Alias

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Gnathodiaphyseal Dysplasia

GDD	Osteogenesis Imperfecta With Unusual Skeletal Lesions
Gnathodiaphyseal Sclerosis	Osteogenesis Imperfecta, Levin Type
Levin Syndrome 2	Dysplasia, Gnathodiaphyseal

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06453	HTATIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HTATIP2	VGNC	VGNC:62854
Mus musculus	HTATIP2	MGD	MGI:1859271
Canis familiaris	HTATIP2	VGNC	VGNC:41821
Rattus norvegicus	HTATIP2	RGD	RGD:1309941
Bos taurus	HTATIP2	VGNC	VGNC:29989

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