SLC34A2 - solute carrier family 34 member 2 Gene

Homo sapiens

Also known as PULAM; NPTIIb; NAPI-3B; NAPI-IIb

Gene ID: 10568 | Gene type: protein coding

About SLC34A2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,655,851-25,678,748 (from NCBI)

This gene has 7 transcripts (splice variants), 296 orthologues, 2 paralogues and is associated with 75 phenotypes. Restricted expression toward lung (RPKM 380.9).

Summary

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

SLC34A2 Products(3)

mRNA	Protein	Name
NM_001177998.2	NP_001171469.2	sodium-dependent phosphate transport protein 2B isoform b
NM_001177999.2	NP_001171470.2	sodium-dependent phosphate transport protein 2B isoform b
NM_006424.3	NP_006415.3	sodium-dependent phosphate transport protein 2B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphate ion binding	IDA IDA: Inferred from direct assay	12488042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sodium ion binding	IDA IDA: Inferred from direct assay	12488042	GOA
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	10329428	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular phosphate ion homeostasis	IDA IDA: Inferred from direct assay	10610722	GOA
involved in phosphate ion transport	IDA IDA: Inferred from direct assay	10329428	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12893629	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15970207	GOA
located in membrane	IDA IDA: Inferred from direct assay	10329428	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC34A2 Protein Structure

Na_Pi_cotrans

0
200
400
600
690 a.a.

Protein Preferred Names

Protein Names

sodium-dependent phosphate transport protein 2B

sodium/phosphate cotransporter 2B

Related Diseases

Diseases

Alias

Pulmonary Alveolar Microlithiasis

PULAM

Pam

Testicular Microlithiasis

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Baritosis

Deposition Of Barium In The Lungs

Inhalation Of Barytes

Pulmonary Hemosiderosis

Idiopathic Pulmonary Hemosiderosis	Alveolar Hypoventilation Syndrome
Brown Induration	Brown Lung
Siderosis	Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Byssinosis

Hypophosphatemic Rickets With Hypercalciuria, Hereditary

Hereditary Hypophosphatemic Rickets With Hypercalciuria	HHRH
Hypophosphatemic Rickets With Hypercalciuria	Hypercalciuric Rickets

Chronic Congestive Splenomegaly

Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic	Bamberger-Marie Disease
Hpoa - Hypertrophic Pulmonary Osteoarthropathy	Hypertrophic Pulmonary Osteoarthropathy
Marie Bamberger Disease

Phosphorus Metabolism Disease

Phosphorus Metabolism Disorders	Disorder Of Phosphorus Metabolism
Phosphorus Disorder	Phosphorus Metabolism Disorder

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V	Hyperchylomicronemia, Late-Onset
Familial Type 5 Hyperlipoproteinemia	Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipidemia, Type V	Hyperlipemia, Mixed
Hyperlipemia, Combined Fat And Carbohydrate-Induced	Familial Hyperlipoproteinemia Type V
Fredrickson Type V Lipaemia	Hyperlipoproteinemia Type 5
Hyperchylomicronemia Late Onset	Hyperlipemia Combined Fat And Carbohydrate-Induced
Hyperlipemia Mixed	Hyperlipidemia Type V
Mixed Hyperlipemia	Type V Hyperlipoproteinemia
Hyperlipoproteinemia 5	HLPP5
Hyperlipidemia, Familial Combined	Mixed Hyperlipidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145894	NaPi2b-IN-2		98.93%	Unkown
HY-146429	NaPi2b-IN-3	Inhibitor	/	Unkown
HY-RS13193	SLC34A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC34A2	VGNC	VGNC:34818
Felis catus	SLC34A2	VGNC	VGNC:65317
Macaca mulatta	SLC34A2	VGNC	VGNC:77459
Mus musculus	SLC34A2	MGD	MGI:1342284
Rattus norvegicus	SLC34A2	RGD	RGD:620889
Canis familiaris	SLC34A2	VGNC	VGNC:46359
Macaca fascicularis	SLC34A2	NCBI	NCBI:102137752
Others	SLC34A2	NCBI

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