TACC2 - transforming acidic coiled-coil containing protein 2 Gene

Homo sapiens

Also known as AZU-1; ECTACC

Gene ID: 10579 | Gene type: protein coding

About TACC2

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:121,989,163-122,254,542 (from NCBI)

This gene has 30 transcripts (splice variants), 199 orthologues and 2 paralogues. Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues.

Summary

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in Cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TACC2 Products(8)

mRNA	Protein	Name
NM_001291876.2	NP_001278805.2	transforming acidic coiled-coil-containing protein 2 isoform e
NM_001291877.2	NP_001278806.2	transforming acidic coiled-coil-containing protein 2 isoform f
NM_001291878.2	NP_001278807.1	transforming acidic coiled-coil-containing protein 2 isoform g
NM_001291879.2	NP_001278808.1	transforming acidic coiled-coil-containing protein 2 isoform h
NM_006997.4	NP_008928.1	transforming acidic coiled-coil-containing protein 2 isoform d
NM_206860.3	NP_996742.1	transforming acidic coiled-coil-containing protein 2 isoform c
NM_206861.3	NP_996743.1	transforming acidic coiled-coil-containing protein 2 isoform b
NM_206862.4	NP_996744.4	transforming acidic coiled-coil-containing protein 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	15207008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACC2 Protein Structure

TACC

0
500
1000
1500
2000
2500
2948 a.a.

Protein Preferred Names

Protein Names

transforming acidic coiled-coil-containing protein 2

anti zuai-1

Related Diseases

Diseases

Alias

Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma

Gastric Diffuse Adenocarcinoma

Diffuse Gastric Adenocarcinoma

Carcinoma, Diffuse Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14140	TACC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TACC2	VGNC	VGNC:78081
Canis familiaris	TACC2	VGNC	VGNC:47064
Felis catus	TACC2	VGNC	VGNC:65919
Rattus norvegicus	TACC2	RGD	RGD:1303004
Mus musculus	TACC2	MGD	MGI:1928899
Bos taurus	TACC2	VGNC	VGNC:35558

Name
Email *

	Sorry, but the email address you supplied was invalid.