GAS2L1 - growth arrest specific 2 like 1 Gene

Homo sapiens

Also known as GAR22

Gene ID: 10634 | Gene type: protein coding

About GAS2L1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,306,650-29,312,787 (from NCBI)

This gene has 10 transcripts (splice variants), 194 orthologues and 7 paralogues. Broad expression in testis (RPKM 11.4), fat (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the Cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]

GAS2L1 Products(6)

mRNA	Protein	Name
NM_001278730.2	NP_001265659.1	GAS2-like protein 1 isoform c
NM_001362985.3	NP_001349914.1	GAS2-like protein 1 isoform a
NM_001395196.1	NP_001382125.1	GAS2-like protein 1 isoform a
NM_001395197.1	NP_001382126.1	GAS2-like protein 1 isoform a
NM_006478.5	NP_006469.2	GAS2-like protein 1 isoform a
NM_152236.3	NP_689422.1	GAS2-like protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal anchor activity	IDA IDA: Inferred from direct assay	12584248	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	12584248	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24706950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	12584248	GOA
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	12584248	GOA
involved in protein localization to microtubule plus-end	IDA IDA: Inferred from direct assay	24706950	GOA
involved in regulation of microtubule polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	24706950	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with actin filament	IMP IMP: Inferred from mutant phenotype	24706950	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12584248	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	12584248	GOA
colocalizes with microtubule plus-end	IMP IMP: Inferred from mutant phenotype	24706950	GOA
colocalizes with stress fiber	IDA IDA: Inferred from direct assay	12584248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAS2L1 Protein Structure

GAS2

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

GAS2-like protein 1

GAS2-related protein on chromosome 22

GAS2L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GAS2L1	Q99501	GPSM2	Homo sapiens	P81274	Y2H Array	32296183
Intra	GAS2L1	Q99501	GPSM2	Homo sapiens	P81274	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05283	GAS2L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GAS2L1	VGNC	VGNC:29258
Mus musculus	GAS2L1	MGD	MGI:1926176
Rattus norvegicus	GAS2L1	RGD	RGD:1311206
Canis familiaris	GAS2L1	VGNC	VGNC:41116
Macaca mulatta	GAS2L1	VGNC	VGNC:72730
Felis catus	GAS2L1	VGNC	VGNC:107706

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