RAD51AP1 - RAD51 associated protein 1 Gene

Homo sapiens

Also known as PIR51

Gene ID: 10635 | Gene type: protein coding

About RAD51AP1

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,538,890-4,560,047 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 9.3), testis (RPKM 6.1) and 20 other tissues.

Summary

Enables nucleic acid binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RAD51AP1 Products(3)

mRNA	Protein	Name
NM_001130862.2	NP_001124334.1	RAD51-associated protein 1 isoform a
NM_001410959.1	NP_001397888.1	RAD51-associated protein 1 isoform c
NM_006479.5	NP_006470.1	RAD51-associated protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-loop DNA binding	IDA IDA: Inferred from direct assay	17996711	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	31253762	GOA
enables DNA secondary structure binding	IDA IDA: Inferred from direct assay	17996710	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	9396801	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	9396801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9396801	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	9396801	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	17996710	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	23754376	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	17996710	GOA
involved in positive regulation of reciprocal meiotic recombination	IDA IDA: Inferred from direct assay	17996711	GOA
involved in regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	23754376	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	26323318	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26323318	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	16990250	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RAD51-associated protein 1

RAD51-interacting protein

RAD51AP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAD51AP1	Q96B01	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Prey Pooling	32296183
Intra	RAD51AP1	Q96B01	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11606	RAD51AP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAD51AP1	RGD	RGD:1597431
Canis familiaris	RAD51AP1	VGNC	VGNC:45318
Bos taurus	RAD51AP1	VGNC	VGNC:58401
Macaca mulatta	RAD51AP1	VGNC	VGNC:76497
Mus musculus	RAD51AP1	MGD	MGI:1098224

Name
Email *

	Sorry, but the email address you supplied was invalid.