TCFL5 - transcription factor like 5 Gene

Homo sapiens

Also known as CHA; Figlb; SOSF1; E2BP-1; bHLHe82

Gene ID: 10732 | Gene type: protein coding

About TCFL5

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,841,005-62,861,822 (from NCBI)

This gene has 2 transcripts (splice variants) and 173 orthologues. Broad expression in testis (RPKM 22.8), thyroid (RPKM 7.1) and 19 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TCFL5 Products(2)

mRNA	Protein	Name
NM_001301726.2	NP_001288655.1	transcription factor-like 5 protein isoform 2
NM_006602.4	NP_006593.2	transcription factor-like 5 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9763657	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12923186	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12923186	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12923186	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9763657	GOA
involved in regulation of cell differentiation	IEP IEP: Inferred from expression pattern	9763657	GOA
involved in regulation of cell population proliferation	IEP IEP: Inferred from expression pattern	9763657	GOA
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	9763657	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9763657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCFL5 Protein Structure

HLH

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

transcription factor-like 5 protein

HPV-16 E2-binding protein 1

Related Diseases

Diseases

Alias

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Bile Duct Cancer

Bile Duct Carcinoma	Extrahepatic Bile Duct Carcinoma
Carcinoma Of Extrahepatic Bile Duct	Extrahepatic Bile Duct Cancer
Bile Duct Neoplasms	Bile Duct Tumor
Ca Extrahepatic Bile Ducts	Malignant Neoplasm Of The Extrahepatic Bile Duct
Bile Duct Extrahepatic Carcinoma	Malignant Tumor Of Extrahepatic Bile Duct

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Mixed Germ Cell-Sex Cord Neoplasm

Mixed Germ Cell-Sex Cord-Stromal Tumor

Mixed Germ Cell-Sex Cord Tumor

Trypanosomiasis

Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Bile Duct Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14311	TCFL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TCFL5	MGD	MGI:2672878
Macaca mulatta	TCFL5	VGNC	VGNC:98458
Felis catus	TCFL5	VGNC	VGNC:81236
Rattus norvegicus	TCFL5	RGD	RGD:1305899
Canis familiaris	TCFL5	VGNC	VGNC:49660

Name
Email *

	Sorry, but the email address you supplied was invalid.