STAG3 - stromal antigen 3 Gene

Homo sapiens

Also known as SPGF61

Gene ID: 10734 | Gene type: protein coding

About STAG3

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,177,724-100,219,334 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 44.6), brain (RPKM 6.1) and 2 other tissues.

Summary

The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

STAG3 Products(5)

mRNA	Protein	Name
NM_001282716.1	NP_001269645.1	cohesin subunit SA-3 isoform 1
NM_001282717.2	NP_001269646.1	cohesin subunit SA-3 isoform 2
NM_001282718.2	NP_001269647.1	cohesin subunit SA-3 isoform 3
NM_001375438.1	NP_001362367.1	cohesin subunit SA-3 isoform 2
NM_012447.4	NP_036579.2	cohesin subunit SA-3 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of meiotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	31682730	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of meiotic cohesin complex	IDA IDA: Inferred from direct assay	21242291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAG3 Protein Structure

STAG

0
200
400
600
800
1000
1225 a.a.

Protein Preferred Names

Protein Names

cohesin subunit SA-3

SCC3 homolog 3

Related Diseases

Diseases

Alias

Premature Ovarian Failure 8

POF8	Ovarian Failure, Premature, Type 8

Spermatogenic Failure 61

SPGF61

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Amenorrhea

Absence Of Menstruation

Amenia

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Orofacial Cleft 8

OFC8	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8
Non-Syndromic Cleft Lip/Palate 8	Non-Syndromic Cleft Lip With Or Without Cleft Palate 8
Orofacial Cleft, Type 8

Bardet-Biedl Syndrome 12

BBS12	Bardet-Biedl Syndrome
Bbs	Bardet-Biedl Syndrome, Type 12

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13868	STAG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STAG3	RGD	RGD:621333
Canis familiaris	STAG3	VGNC	VGNC:54072
Macaca mulatta	STAG3	VGNC	VGNC:81766
Mus musculus	STAG3	MGD	MGI:1355311
Felis catus	STAG3	VGNC	VGNC:80685
Bos taurus	STAG3	VGNC	VGNC:97313

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