Acaca - acetyl-Coenzyme A carboxylase alpha Gene

Mus musculus

Also known as Acac; Acc1; Gm738; A530025K05Rik

Gene ID: 107476 | Gene type: protein coding

About Acaca

Chromosome 11: 84,020,498-84,292,477 forward strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 5 phenotypes. Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues.

Summary

Enables Acetyl-CoA Carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (Acetyl-CoA Carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Acaca Products(1)

mRNA	Protein	Name
NM_133360.3	NP_579938.2	acetyl-CoA carboxylase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyl-CoA carboxylase activity	IDA IDA: Inferred from direct assay	20952656	MGI
enables acetyl-CoA carboxylase activity	IGI IGI: Inferred from genetic interaction	17210641	MGI
enables acetyl-CoA carboxylase activity	IMP IMP: Inferred from mutant phenotype	8954960	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20457939	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetyl-CoA metabolic process	IDA IDA: Inferred from direct assay	20952656	MGI
acts upstream of or within cellular response to prostaglandin E stimulus	IDA IDA: Inferred from direct assay	23479225	MGI
involved in fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	20952656	MGI
involved in lipid biosynthetic process	IGI IGI: Inferred from genetic interaction	17210641	MGI
involved in lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16717184	MGI
acts upstream of or within lipid homeostasis	IMP IMP: Inferred from mutant phenotype	17210641	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	17210641	MGI
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	20952656	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	17210641	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	17210641	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	16717184	MGI
located in cytosol	IDA IDA: Inferred from direct assay	20952656	MGI
is active in cytosol	IGI IGI: Inferred from genetic interaction	17210641	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acaca Protein Structure

AccC

AccB

Biotin_lipoyl

ACC_central

Carboxyl_trans

0
400
800
1200
1600
2000
2345 a.a.

Protein Preferred Names

Protein Names

acetyl-CoA carboxylase 1

ACC-alpha

acetyl-CoA carboxylase 265

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00119	ACACA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00120	Acaca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00121	Acaca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acaca	NCBI	NCBI:31
Macaca fascicularis	Acaca	NCBI	NCBI:102138812
Macaca mulatta	Acaca	NCBI	NCBI:714218

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