2. Gene
  3. Grm5 - glutamate receptor, metabotropic 5 Gene

Grm5 - glutamate receptor, metabotropic 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik

Gene ID: 108071 | Gene type: protein coding

About Grm5

Chromosome 7: 87,233,376-87,784,115 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 23 phenotypes. Biased expression in CNS E18 (RPKM 1.5), frontal lobe adult (RPKM 8.7) and 4 other tissues.

Summary

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of age-related behavioral decline. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 Products(2)

mRNA Protein Name
NM_001143834.1 NP_001137306.1 metabotropic glutamate receptor 5 isoform b precursor
NM_001081414.2 NP_001074883.1 metabotropic glutamate receptor 5 isoform a precursor

Grm5 Protein Structure

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (25 - 495)

NCD3G

NCD3G: pfam07562 (506 - 556)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 825)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 601)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (613 - 634)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (643 - 667)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (691 - 711)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (734 - 760)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (768 - 791)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (794 - 819)

DUF5585

DUF5585: cl39316 (1006 - 1184)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1152 - 1202)

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  • 1203 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 5

G protein-coupled receptor GRM5

G protein-coupled receptor, family C, group 1, member E

metabotropic glutamate receptor subtype 5b

metabotropic glutamate receptor type 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05831 GRM5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05832 Grm5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05833 Grm5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm5 NCBI NCBI:2915