Grm6 - glutamate receptor, metabotropic 6 Gene

Mus musculus

Also known as Gm3; nob2; nob3; nob4; nerg1; Gprc1f; mGluR6

Gene ID: 108072 | Gene type: protein coding

About Grm6

Chromosome 11: 50,741,512-50,757,035 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 250 orthologues, 7 paralogues and is associated with 20 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity and protein homodimerization activity. Involved in locomotory behavior and sensory perception of light stimulus. Acts upstream of or within retina development in camera-type eye and signal transduction. Located in new growing cell tip. Is expressed in prostate gland; retina inner nuclear layer; and testis. Used to study congenital stationary night blindness 1B. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Grm6 Products(1)

mRNA	Protein	Name
NM_173372.2	NP_775548.2	metabotropic glutamate receptor 6 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	36179691	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	10842024	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
involved in sensory perception of light stimulus	IMP IMP: Inferred from mutant phenotype	10842024	MGI
acts upstream of or within signal transduction	IGI IGI: Inferred from genetic interaction	19966281	MGI
acts upstream of or within synapse assembly	IMP IMP: Inferred from mutant phenotype	36179691	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell tip	IDA IDA: Inferred from direct assay	25997951	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	25997951	MGI
located in new growing cell tip	IDA IDA: Inferred from direct assay	19966281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm6 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tm_GPCRs

0
200
400
600
800
871 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 6

G protein-coupled receptor GRM6

G protein-coupled receptor, family C, group 1, member F

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05834	GRM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05835	Grm6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05836	Grm6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm6	NCBI	NCBI:2916

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