Grm7 - glutamate receptor, metabotropic 7 Gene

Mus musculus

Also known as SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb

Gene ID: 108073 | Gene type: protein coding

About Grm7

Chromosome 6: 110,622,542-111,544,191 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 22 phenotypes. Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues.

Summary

Enables Calcium Channel regulator activity and voltage-gated Calcium Channel activity. Involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 Products(2)

mRNA	Protein	Name
NM_001346640.1	NP_001333569.1	metabotropic glutamate receptor 7 isoform 2 precursor
NM_177328.3	NP_796302.2	metabotropic glutamate receptor 7 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	11584003	MGI
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	12065412	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	12814372	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	16775145	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	9920659	MGI
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	12065412	MGI
acts upstream of or within conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	9920659	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	16204199	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	12814372	MGI
acts upstream of or within nervous system process	IMP IMP: Inferred from mutant phenotype	16204199	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	12065412	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12065412	MGI
acts upstream of or within short-term memory	IMP IMP: Inferred from mutant phenotype	15313036	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	11698585	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12065412	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12065412	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12065412	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm7 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR7

0
200
400
600
800
915 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 7

G protein-coupled receptor GRM7	G protein-coupled receptor, family C, group 1, member G
mGlu7a receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm7	NCBI	NCBI:2917

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