WDR3 - WD repeat domain 3 Gene

Homo sapiens

Also known as DIP2; UTP12

Gene ID: 10885 | Gene type: protein coding

About WDR3

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:117,929,739-117,966,543 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 13.4), appendix (RPKM 7.9) and 25 other tissues.

Summary

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

WDR3 Products(1)

mRNA	Protein	Name
NM_006784.3	NP_006775.1	WD repeat-containing protein 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR3 Protein Structure

WD40

Utp12

0
200
400
600
800
943 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 3

dJ776P7.2 (WD repeat domain 3)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15772	WDR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WDR3	VGNC	VGNC:78789
Mus musculus	WDR3	MGD	MGI:2443143
Canis familiaris	WDR3	VGNC	VGNC:48359
Rattus norvegicus	WDR3	RGD	RGD:1307480
Bos taurus	WDR3	VGNC	VGNC:36890
Felis catus	WDR3	VGNC	VGNC:67024
Others	WDR3	NCBI

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