MMP24 - matrix metallopeptidase 24 Gene

Homo sapiens

Also known as MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5

Gene ID: 10893 | Gene type: protein coding

About MMP24

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,226,690-35,276,998 (from NCBI)

This gene has 1 transcript (splice variant), 198 orthologues and 23 paralogues. Broad expression in kidney (RPKM 9.9), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature Protease. Unlike most MMPs, which are secreted, this Protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this Protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

MMP24 Products(1)

mRNA	Protein	Name
NM_006690.4	NP_006681.1	matrix metalloproteinase-24 preproprotein

MMP24 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

DUF3377

0
100
200
300
400
500
600
645 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-24

matrix metallopeptidase 24 (membrane-inserted)

Related Diseases

Diseases

Alias

Acromesomelic Dysplasia 2c

Acromesomelic Dysplasia, Hunter-Thompson Type	Acromesomelic Dysplasia 2c, Hunter-Thompson Type
AMD2C	Acromesomelic Dwarfism
Amdh Acromesomelic Dwarfism	Acromesomelic Dysplasia-2c
Acromesomelic Dysplasia Hunter Thompson Type	Acromesomelic Chondrodysplasia, Hunter-Thompson Type
Amdh	Dysplasia, Acromesomelic, Type 2c, Hunter-Thompson
Acromesomelic Dysplasia Hunter-Thompson Type

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Asymptomatic Dengue

Suppurative Periapical Periodontitis

Periapical Abscess	Apical Abscess
Suppurative Apical Periodontitis	Dentoalveolar Abscess
Dental Abscess With Sinus	Dentoalveolar Abscess With Sinus
Dental Sinus	Periapical Abscess Fistula
Apical Tooth Abscess	Apex Abscess
Dental Abscess Nos	Infection Of Tooth Nos
Abscess Of Tooth	Dental Infection Nos

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil	Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Casil	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Familial Vascular Leukoencephalopathy	CADASIL1
Cadasil 1	Hereditary Multi-Infarct Dementia
Cadasil Syndrome	Dementia, Hereditary Multiinfarct Type
Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1	Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy	Dementia, Hereditary Multi-Infarct Type
Hereditary Dementia, Multi-Infarct Type	Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant
Dementia Hereditary Multiinfarct Type	Dementia Hereditary Multi-Infarct Type
Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08543	MMP24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MMP24	RGD	RGD:620202
Canis familiaris	MMP24	VGNC	VGNC:43283
Mus musculus	MMP24	MGD	MGI:1341867
Bos taurus	MMP24	VGNC	VGNC:31526
Felis catus	MMP24	VGNC	VGNC:68289
Macaca mulatta	MMP24	VGNC	VGNC:74899

Name
Email *

	Sorry, but the email address you supplied was invalid.