BRD8 - bromodomain containing 8 Gene

Homo sapiens

Also known as SMAP; p120; SMAP2

Gene ID: 10902 | Gene type: protein coding

About BRD8

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,139,770-138,178,630 (from NCBI)

This gene has 26 transcripts (splice variants) and 291 orthologues. Broad expression in testis (RPKM 45.3), brain (RPKM 10.9) and 23 other tissues.

Summary

The protein encoded by this gene interacts with Thyroid Hormone Receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

BRD8 Products(6)

mRNA	Protein	Name
NM_001164326.2	NP_001157798.1	bromodomain-containing protein 8 isoform 4
NM_001300961.3	NP_001287890.1	bromodomain-containing protein 8 isoform 5
NM_001300962.3	NP_001287891.1	bromodomain-containing protein 8 isoform 6
NM_001300966.3	NP_001287895.1	bromodomain-containing protein 8 isoform 7
NM_006696.5	NP_006687.3	bromodomain-containing protein 8 isoform 1
NM_139199.2	NP_631938.2	bromodomain-containing protein 8 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	9368056	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	9368056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to thyroid hormone stimulus	IDA IDA: Inferred from direct assay	9368056	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9368056	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	14966270	GOA
part of Swr1 complex	IDA IDA: Inferred from direct assay	24463511	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD8 Protein Structure

Bromodomain

0
200
400
600
800
1000
1235 a.a.

Protein Preferred Names

Protein Names

bromodomain-containing protein 8

skeletal muscle abundant protein 2

Related Diseases

Diseases

Alias

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules	Ovarian Sex Cord-Stromal Tumor
Stromal Tumor Of Ovary

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148116	DN02	Inhibitor	99.17%	Unkown
HY-RS01609	BRD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BRD8	VGNC	VGNC:70350
Mus musculus	BRD8	MGD	MGI:1925906
Felis catus	BRD8	VGNC	VGNC:60170
Rattus norvegicus	BRD8	RGD	RGD:1307003

Name
Email *

	Sorry, but the email address you supplied was invalid.