TRAFD1 - TRAF-type zinc finger domain containing 1 Gene

Homo sapiens

Also known as FLN29

Gene ID: 10906 | Gene type: protein coding

About TRAFD1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,125,560-112,153,604 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 16.4) and 25 other tissues.

Summary

The innate immune system confers host defense against viral and microbial Infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

TRAFD1 Products(2)

mRNA	Protein	Name
NM_001143906.2	NP_001137378.1	TRAF-type zinc finger domain-containing protein 1
NM_006700.3	NP_006691.1	TRAF-type zinc finger domain-containing protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TRAF-type zinc finger domain-containing protein 1

FLN29 gene product

Related Diseases

Diseases

Alias

Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus

Central Nervous System Tuberculosis

Intracranial Tuberculoma	Tuberculoma Of Brain
Tuberculosis Of Meninges And Central Nervous System	Tuberculous Abscess Of Brain
Tuberculoma, Intracranial	Tuberculosis, Central Nervous System

Type 1 Diabetes Mellitus 3

Diabetes Mellitus, Insulin-Dependent, 3	Iddm3
Insulin-Dependent Diabetes Mellitus 3	T1D3

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14977	TRAFD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRAFD1	RGD	RGD:620171
Felis catus	TRAFD1	VGNC	VGNC:66503
Bos taurus	TRAFD1	VGNC	VGNC:97319
Macaca mulatta	TRAFD1	VGNC	VGNC:79459
Canis familiaris	TRAFD1	VGNC	VGNC:47771
Mus musculus	TRAFD1	MGD	MGI:1923551

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