KLK11 - kallikrein related peptidase 11 Gene

Homo sapiens

Also known as TLSP; PRSS20

Gene ID: 11012 | Gene type: protein coding

About KLK11

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,022,236-51,027,991 (from NCBI)

This gene has 11 transcripts (splice variants), 171 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

KLK11 Products(4)

mRNA	Protein	Name
NM_001136032.3	NP_001129504.1	kallikrein-11 isoform 1 precursor
NM_001167605.2	NP_001161077.1	kallikrein-11 isoform 3 precursor
NM_006853.3	NP_006844.1	kallikrein-11 isoform 1 precursor
NM_144947.3	NP_659196.1	kallikrein-11 isoform 2

KLK11 Protein Structure

Trypsin

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

kallikrein-11

hK11

Recombinant KLK11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7381	Kallikrein-11 Protein, Human (Sf9)	Q9UBX7-2 (E51-N282)	≥95%
HY-P73263	Kallikrein-11 Protein, Human (HEK293, His)	Q9UBX7-1 (E19-N250)	≥95%

Related Diseases

Diseases

Alias

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis	Chronic Ethmoid Sinusitis
Ethmoidal Sinusitis - Chronic

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07375	KLK11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KLK11	VGNC	VGNC:67962
Mus musculus	KLK11	MGD	MGI:1929977
Canis familiaris	KLK11	VGNC	VGNC:42479
Bos taurus	KLK11	VGNC	VGNC:30673
Rattus norvegicus	KLK11	RGD	RGD:1308690

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