LILRB3 - leukocyte immunoglobulin like receptor B3 Gene

Homo sapiens

Also known as HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6

Gene ID: 11025 | Gene type: protein coding

About LILRB3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,216,278-54,223,007 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 317 orthologues and 25 paralogues. Biased expression in appendix (RPKM 14.3), bone marrow (RPKM 8.1) and 7 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB3 Products(3)

mRNA	Protein	Name
NM_001081450.3	NP_001074919.2	leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor
NM_001320960.2	NP_001307889.1	leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 3 precursor
NM_006864.4	NP_006855.3	leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables amyloid-beta binding	IDA IDA: Inferred from direct assay	24052308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18802077	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	18802077	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB3 Protein Structure

Ig_2

Ig_3

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names

Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 3

CD85 antigen-like family member A

Recombinant LILRB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75912	LILRB3/CD85a Protein, Human (HEK293, Fc)	AAI04994.1 (G24-E443)	≥95%
HY-P75913	LILRB3/CD85a Protein, Human (Biotinylated, HEK293, His)	O75022 (G24-E443)	≥95%
HY-P75914	LILRB3/CD85a Protein, Human (HEK293, His)	O75022 (G24-E443)	≥95%
HY-P78171	LILRB3/CD85a Protein, Human (Biotinylated, HEK293, His-Avi)	O75022 (G24-E443)	≥95%
HY-P78484	LILRB3/CD85a Protein, Human (HEK293, His-Avi)	O75022 (G24-E443)	≥95%

Related Diseases

Diseases

Alias

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07653	LILRB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LILRB3	RGD	RGD:1589827
Mus musculus	LILRB3	NCBI

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