2. Gene
  3. MID2 - midline 2 Gene

MID2 - midline 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FXY2; RNF60; TRIM1; MRX101; XLID101

Gene ID: 11043 | Gene type: protein coding

About MID2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,825,735-107,931,637 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 80 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.8), fat (RPKM 3.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

MID2 Products(4)

mRNA Protein Name
NM_001382751.1 NP_001369680.1 probable E3 ubiquitin-protein ligase MID2 isoform 3
NM_001382752.1 NP_001369681.1 probable E3 ubiquitin-protein ligase MID2 isoform 4
NM_012216.4 NP_036348.2 probable E3 ubiquitin-protein ligase MID2 isoform 1
NM_052817.3 NP_438112.2 probable E3 ubiquitin-protein ligase MID2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
11806752 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
11806752 GOA
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
11806752 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11806752 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
23077300 GOA
Biological Process GO Annotation Evidence Reference Source
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: Inferred from direct assay
18248090 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
23077300 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
23077300 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
26347139 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23077300 GOA
involved in protein localization to microtubule IMP
IMP: Inferred from mutant phenotype
11806752 GOA
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with microtubule IDA
IDA: Inferred from direct assay
10400986 GOA
located in microtubule IDA
IDA: Inferred from direct assay
11806752 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MID2 Protein Structure

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (27 - 83)

zf-B_box

zf-B_box: B-box zinc finger (193 - 231)

SPRY

SPRY: SPRY domain (588 - 697)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase MID2

RING finger protein 60

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, X-Linked 101

XLID101

Mental Retardation, X-Linked 101

Mrx101

Mental Retardation, X-Linked, Type 101
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Opitz Gbbb Syndrome

Opitz G/Bbb Syndrome

Opitz Syndrome

Hypertelorism-Hypospadias Syndrome

Hypertelorism With Esophageal Abnormality And Hypospadias

Opitz-Frias Syndrome

Os

Osx

Telecanthus-Hypospadias Syndrome

Opitz Gbbb Syndrome Type I

Opitz Bbbg Syndrome

Hypospadias-Dysphagia Syndrome

Opitz Bbb/G Syndrome

GBBB

Opitz Gbbb Syndrome, X-Linked

Opitz Syndrome, X-Linked

Opitz Gbbb Syndrome, Type I, Formerly

Gbbb1, Formerly

Opitz-G Syndrome, Type I, Formerly

Ogs1, Formerly

Opitz Bbbg Syndrome, Type I, Formerly

Bbbg1, Formerly

Bbb Syndrome

G Syndrome

Gbbb Syndrome

Hypertelorism Hypospadias Syndrome

Hypospadias-Dysphagia, Syndrome

Opitz-G Syndrome, Type 2

Telecanthus With Associated Abnormalities

Hypertelorism With Esophageal Abnormalities And Hypospadias

Hypertelorism-Hypospadias Sydrome

Opitz Bbb Syndrome

Opitz G Syndrome

Hypertelorism-Oesophageal Abnormality-Hypospadias Syndrome

Opitz Gbbb Syndrome 1

GBBB1

Bbbg1

Gggb1

Opitz Bbbg Syndrome Type I

Opitz Gbbb Syndrome X-Linked

Opitz-G Syndrome Type I

Opitz Syndrome X-Linked

Opitz G Syndrome, Type I

Opitz Bbbg Syndrome, Type I
Hypospadias

Hypospadias Familial

Familial Hypospadias
Non-Syndromic X-Linked Intellectual Disability 63

Acsl4-Related Intellectual Disability

Mrx63

Mrx68

X-Linked Mental Retardation 68
Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101
Myringitis Bullosa Hemorrhagica

Bullous Myringitis
Non-Syndromic X-Linked Intellectual Disability 30

Mrx30

Mrx47

X-Linked Mental Retardation 30/47

X-Linked Mental Retardation 47

Mental Retardation, X-Linked, Type 30/47
Tetanus Neonatorum

Neonatal Tetanus

NNT

Trismus Neonatorum

Newborn Trismus
Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Urinary Schistosomiasis

Schistosoma Haematobium Infection

Schistosoma Hematobium Infection

Schistosomiasis Due To Schistosoma Haematobium

Bladder Schistosomiasis

Cystitis With Bilharziasis

Schistosoma Haematobium

Schistosoma Hematobium Infectious Disease

Schistosomiasis Of Bladder

Vesical Schistosomiasis

Schistosomiasis Urinary

Schistosomiasis Haematobia

Genitourinary Bilharziasis

Genitourinary Tract Schistosomiasis

Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

Haematochyluria In Schistosomiasis

Infection Due To Schistosoma Matthei
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08436 MID2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MID2 VGNC VGNC:43224
Mus musculus MID2 MGD MGI:1344333
Macaca mulatta MID2 VGNC VGNC:74722
Rattus norvegicus MID2 RGD RGD:1565674
Bos taurus MID2 VGNC VGNC:106822
Felis catus MID2 VGNC VGNC:68256