ZPBP - zona pellucida binding protein Gene

Homo sapiens

Also known as ZPBP1; SPGF66

Gene ID: 11055 | Gene type: protein coding

About ZPBP

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:49,840,654-50,093,246 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues, 1 paralogue and is associated with 1 phenotype. Restricted expression toward testis (RPKM 37.4).

Summary

ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]

ZPBP Products(2)

mRNA	Protein	Name
NM_001159878.2	NP_001153350.1	zona pellucida-binding protein 1 isoform 2 precursor
NM_007009.3	NP_008940.2	zona pellucida-binding protein 1 isoform 1 precursor

ZPBP Protein Structure

Sp38

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

zona pellucida-binding protein 1

inner acrosomal membrane IAM38

Related Diseases

Diseases

Alias

Spermatogenic Failure 66

SPGF66

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16190	ZPBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZPBP	VGNC	VGNC:108457
Bos taurus	ZPBP	VGNC	VGNC:37368
Mus musculus	ZPBP	MGD	MGI:1855701
Felis catus	ZPBP	VGNC	VGNC:67375
Canis familiaris	ZPBP	VGNC	VGNC:48844
Rattus norvegicus	ZPBP	RGD	RGD:1563985

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