CNMD - chondromodulin Gene

Homo sapiens

Also known as CHM1; CHM-I; LECT1; BRICD3; MYETS1

Gene ID: 11061 | Gene type: protein coding

About CNMD

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,703,264-52,739,820 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 1 paralogue. Biased expression in thyroid (RPKM 1.5), salivary gland (RPKM 1.3) and 3 other tissues.

Summary

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CNMD Products(2)

mRNA	Protein	Name
NM_001011705.2	NP_001011705.1	leukocyte cell-derived chemotaxin 1 isoform 2 precursor
NM_007015.3	NP_008946.1	leukocyte cell-derived chemotaxin 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	16980969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNMD Protein Structure

BRICHOS

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

leukocyte cell-derived chemotaxin 1

BRICHOS domain containing 3

Recombinant CNMD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75906	LECT1 Protein, Human (HEK293, Fc)	O75829-1 (E215-V333)	≥95%

Related Diseases

Diseases

Alias

Infective Endocarditis

Bacterial Endocarditis	Endocarditis, Infective
Infectious Endocarditis	Endocarditis Infective

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Heart Valve Disease

Heart Valve Diseases	Valvular Heart Disease
Valvular Heart Diseases	Heart Valve Prolapse

Aortic Valve Disease 2

Aortic Valve Stenosis	Aortic Stenosis
Rheumatic Aortic Stenosis	AOVD2
Bicuspid Aortic Valve	Rheumatic Aortic Valve Stenosis
Valvular Aortic Stenosis	Aortic Valve Disease, Type 2
Aortic Valve Stricture	Aortic Valve Obstruction
Obstructed Aorta Valve	Rheumatic Aortic Obstruction
Rheumatic Aortic Valve Obstruction	Rheumatic Aortic Stricture
Aortic Valve Regurgitation	Aortic Insufficiency With Stenosis
Rheumatic Aortic Valve Stenosis With Insufficiency	Rheumatic Aortic Stenosis With Incompetence
Rheumatic Aortic Stenosis With Regurgitation

Hydrolethalus Syndrome 2

HLS2	Hydrolethalus Syndrome, Type 2

Pleomorphic Adenoma

Mixed Tumor Of The Salivary Gland	Adenoma Pleomorphic
Adenoma, Pleomorphic	Mixed Salivary Gland Tumor
Mixed Tumor, Not Otherwise Specified

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02891	CNMD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CNMD	VGNC	VGNC:27507
Canis familiaris	CNMD	VGNC	VGNC:54287
Rattus norvegicus	CNMD	RGD	RGD:620176
Macaca mulatta	CNMD	VGNC	VGNC:71191
Mus musculus	CNMD	MGD	MGI:1341171
Felis catus	CNMD	VGNC	VGNC:61020
Others	CNMD	NCBI

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