2. Gene
  3. DUSP14 - dual specificity phosphatase 14 Gene

DUSP14 - dual specificity phosphatase 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MKP6; MKP-L

Gene ID: 11072 | Gene type: protein coding

About DUSP14

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:37,488,566-37,513,498 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 124 orthologues and 30 paralogues. Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP14 Products(1)

mRNA Protein Name
NM_007026.4 NP_008957.1 dual specificity protein phosphatase 14
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP14 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (34 - 164)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 14

MAP kinase phosphatase 6

Recombinant DUSP14 Proteins

Cat. No. Product Name Accession Purity
HY-P76307 DUSP14 Protein, Human (His) O95147 (M1-H191) ≥95%

Related Diseases

Diseases Alias
Variola Major

Smallpox
Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome

Del(17)(Q12)

Monosomy 17q12
Frontometaphyseal Dysplasia

Fmd

Dysplasia, Frontometaphyseal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112478 PTP Inhibitor IV Inhibitor 99.90% Unkown
HY-RS04055 DUSP14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DUSP14 VGNC VGNC:40129
Rattus norvegicus DUSP14 RGD RGD:1307415
Macaca mulatta DUSP14 VGNC VGNC:71851
Felis catus DUSP14 VGNC VGNC:61662
Mus musculus DUSP14 MGD MGI:1927168
Bos taurus DUSP14 VGNC VGNC:28252
Others DUSP14 NCBI