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  2. Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Mus musculus

Also known as MR; Mlr

Gene ID: 110784 | Gene type: protein coding

About Nr3c2

Chromosome 8: 77,626,070-77,971,641 forward strand.GRCm39:CM001001.3

This gene has 8 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 23 phenotypes. Broad expression in colon adult (RPKM 12.), frontal lobe adult (RPKM 3.4) and 2 other tissues.

Summary

Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 Products(1)

mRNA Protein Name
NM_001083906.2 NP_001077375.1 mineralocorticoid receptor

Nr3c2 Protein Structure

Herpes_BLLF1

Herpes_BLLF1: cl37540 (199 - 393)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (598 - 672)

NR_LBD_MR

NR_LBD_MR: cd07075 (732 - 979)

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  • 980 a.a.
Protein Preferred Names Protein Names

mineralocorticoid receptor

aldosterone receptor

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr3c2 NCBI NCBI:4306