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  2. Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Mus musculus

Also known as MR; Mlr

Gene ID: 110784 | Gene type: protein coding

About Nr3c2

Chromosome 8: 77,626,070-77,971,641 forward strand.GRCm39:CM001001.3

This gene has 8 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 23 phenotypes. Broad expression in colon adult (RPKM 12.), frontal lobe adult (RPKM 3.4) and 2 other tissues.

Summary

Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 Products(1)

mRNA Protein Name
NM_001083906.2 NP_001077375.1 mineralocorticoid receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11809749 MGI
enables steroid binding IDA
IDA: Inferred from direct assay
11809749 MGI
Biological Process GO Annotation Evidence Reference Source
involved in angiotensin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
24206662 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
9689096 MGI
involved in potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
24206662 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
18547242 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
18547242 MGI
involved in regulation of blood volume by renal aldosterone IMP
IMP: Inferred from mutant phenotype
24206662 MGI
involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
18547242 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
18547242 MGI
involved in regulation of potassium:proton exchanging ATPase activity IDA
IDA: Inferred from direct assay
24206662 MGI
acts upstream of or within renal sodium excretion IMP
IMP: Inferred from mutant phenotype
9689096 MGI
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
24206662 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
18547242 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
18547242 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
18547242 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18547242 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c2 Protein Structure

Herpes_BLLF1

Herpes_BLLF1: cl37540 (199 - 393)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (598 - 672)

NR_LBD_MR

NR_LBD_MR: cd07075 (732 - 979)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 980 a.a.
Protein Preferred Names Protein Names

mineralocorticoid receptor

aldosterone receptor

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr3c2 NCBI NCBI:4306