DNAJB4 - DnaJ heat shock protein family (Hsp40) member B4 Gene

Homo sapiens

Also known as DjB4; HLJ1; DNAJW

Gene ID: 11080 | Gene type: protein coding

About DNAJB4

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,979,175-78,017,964 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 27.3), thyroid (RPKM 23.6) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

DNAJB4 Products(6)

mRNA	Protein	Name
NM_001317099.2	NP_001304028.1	dnaJ homolog subfamily B member 4 isoform a
NM_001317100.2	NP_001304029.1	dnaJ homolog subfamily B member 4 isoform b
NM_001317101.2	NP_001304030.1	dnaJ homolog subfamily B member 4 isoform c
NM_001317102.2	NP_001304031.1	dnaJ homolog subfamily B member 4 isoform c
NM_001317103.2	NP_001304032.1	dnaJ homolog subfamily B member 4 isoform d
NM_007034.5	NP_008965.2	dnaJ homolog subfamily B member 4 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21255413	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	36264506	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB4 Protein Structure

DnaJ

DnaJ_C

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily B member 4

DnaJ (Hsp40) homolog, subfamily B, member 4

DNAJB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJB4	Q9UDY4	RUVBL2	Homo sapiens	Q9Y230	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03867	DNAJB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJB4	VGNC	VGNC:80183
Bos taurus	DNAJB4	VGNC	VGNC:55166
Rattus norvegicus	DNAJB4	RGD	RGD:1305826
Macaca mulatta	DNAJB4	VGNC	VGNC:106351
Mus musculus	DNAJB4	MGD	MGI:1914285
Canis familiaris	DNAJB4	VGNC	VGNC:49082

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